Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
J Neurointerv Surg. 2014 Apr 1;6(3):178-83. doi: 10.1136/neurintsurg-2013-010669. Epub 2013 Apr 23.
Previous studies have described a correlation between variants of the circle of Willis and pathological findings, such as cerebrovascular diseases. Moreover, anatomic variations of the anterior cerebral artery (ACA) seem to correspond to the prevalence of aneurysms in the anterior communicating artery (ACoA). The aim of this study was to assess the prevalence of aneurysms in patients with anatomical/morphological variations of the circle of Willis.
We retrospectively analyzed 223 patients who underwent cerebral angiography between January 2002 and December 2010 for aneurysm of the ACoA. Diagnostic imaging was reviewed and statistically evaluated to detect circle of Willis anomalies, aneurysm size, and rupture. 204 patients with an unrelated diagnosis served as the control group.
Variations of the A1 segment occurred significantly more frequently in the aneurysm group than in the control group. Mean aneurysm size in patients with grades I and III hypoplasia or aplasia was 6.58 mm whereas in patients with grade II hypoplasia it was 7.76 mm.
We found that variations in the A1 segment of the ACAs are correlated with a higher prevalence of ACoA aneurysms compared with patients with a symmetric circle of Willis.
先前的研究已经描述了 Willis 环的变异与诸如脑血管疾病等病理发现之间的相关性。此外，大脑前动脉（ACA）的解剖变异似乎与前交通动脉（ACoA）动脉瘤的发生率相对应。本研究的目的是评估具有 Willis 环解剖/形态变异的患者中动脉瘤的发生率。
我们回顾性分析了 2002 年 1 月至 2010 年 12 月期间因 ACoA 动脉瘤而行脑动脉造影的 223 例患者。对诊断影像学进行了回顾性分析和统计学评估，以检测 Willis 环异常、动脉瘤大小和破裂。204 例无相关诊断的患者作为对照组。
动脉瘤组的 A1 段变异明显多于对照组。I 级和 III 级发育不良或发育不全患者的平均动脉瘤大小为 6.58mm，而 II 级发育不良患者的平均动脉瘤大小为 7.76mm。
我们发现，ACA 的 A1 段变异与 ACoA 动脉瘤的发生率较高相关，而与对称 Willis 环的患者相比。
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