McCormick C P, Shihabi Z K, Konen J C, Goodman H O, Blizard D A
Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, N.C.
Clin Physiol Biochem. 1990;8(2):59-63.
We studied albumin and transferrin excretion in the normal and diabetic rat: (1) The rat secretes small concentrations of albumin and transferrin in the urine. (2) The secretion depends on the strain and was highest in the Kyoto spontaneously hypertensive rat. (3) The secretion of these two proteins in the rat is quite dependent on age and sex. The level increases dramatically with age. The secretion is much higher in the male compared to the female. This difference is observed after puberty. The changes in transferrin relative to those in albumin are much higher. (4) In streptozotocin-induced diabetes, the concentration of albumin and transferrin expressed as milligrams per liter decreases; however, the output/24 h or per gram creatinine is increased with a greater increase in transferrin output relative to that of albumin. The similarities and differences between excretion of these two proteins in the human and the rat as well as their importance are discussed.
（1）大鼠尿液中分泌低浓度的白蛋白和转铁蛋白。（2）这种分泌取决于大鼠品系，在京都自发性高血压大鼠中最高。（3）大鼠中这两种蛋白质的分泌相当依赖于年龄和性别。其水平随年龄急剧增加。雄性大鼠的分泌量比雌性高得多。这种差异在青春期后出现。转铁蛋白相对于白蛋白的变化要大得多。（4）在链脲佐菌素诱导的糖尿病中，以毫克每升表示的白蛋白和转铁蛋白浓度降低；然而，每24小时或每克肌酐的排出量增加，且转铁蛋白排出量相对于白蛋白增加得更多。本文讨论了这两种蛋白质在人和大鼠排泄情况中的异同及其重要性。
