Department of Neurosurgery, University of California San Francisco, San Francisco, California, United States of America.
PLoS One. 2013 Apr 16;8(4):e61422. doi: 10.1371/journal.pone.0061422. Print 2013.
In the mature eye, three distinct tissue fates, retina, ciliary body, and iris, arrange with a strict linear organization along the central (back) to peripheral (front) axis. The establishment of this topographical relationship within the optic vesicle is not well understood. We use a targeted vital labeling strategy to test the derivation of mature eye tissues from the optic vesicle of the chick embryo. Fate mapping uncovers two distinct origins of the neural retina. Contrary to expectations, the central neural retina has a discrete origin within the posterior optic vesicle. The peripheral retina derives from the distal optic vesicle, sharing a common origin with more peripheral tissue fates. This study identifies for the first time two distinct retinal sub-domains, central and peripheral, which arise during embryogenesis. Identification of these discrete retinal compartments provides a framework for understanding functional and disease processes throughout retinal tissue.
在成熟的眼睛中，三种不同的组织命运，视网膜、睫状体和虹膜，沿着中央（背部）到周边（前部）轴严格地线性排列。然而，这种在视泡内的拓扑关系的建立还不是很清楚。我们使用一种靶向的活体标记策略来测试成熟眼睛组织是否来源于鸡胚的视泡。命运映射揭示了神经视网膜的两个不同起源。与预期相反，中央神经视网膜在后视泡中有一个离散的起源。周边视网膜来自于远端视泡，与更周边的组织命运具有共同的起源。这项研究首次确定了两个不同的视网膜亚区，中央和周边，它们在胚胎发生过程中出现。这些离散的视网膜隔室的鉴定为理解整个视网膜组织的功能和疾病过程提供了一个框架。
