Public Health Institute Maribor, Maribor, Slovenia.
Altern Lab Anim. 2013 Mar;41(1):65-75. doi: 10.1177/026119291304100108.
The environmental fate and effects of triazoles and benzotriazoles are of concern within the context of chemical regulation. As part of an intelligent testing strategy, experimental tests were performed on endpoints that are relevant for risk assessment. The experimental tests included the assessment of ecotoxicity to an alga, a daphnid and zebrafish embryos, and the assessment of ready biodegradability. Triazole and benzotriazole compounds were selected for testing, based on existing toxicity data for vertebrate and invertebrate species, as well as on the principal component analysis of molecular descriptors aimed at selecting the minimum number of test compounds in order to maximise the chemical domain spanned for both compound classes. The experimental results show that variation in the toxicities of triazoles and benzotriazole across species was relatively minor; in general, the largest factor was approximately 20. The study conducted indicated that triazoles are not readily biodegradable.
唑类和苯并三唑类化合物的环境归宿和效应是化学品监管方面关注的问题。作为智能测试策略的一部分，对与风险评估相关的终点进行了实验测试。实验测试包括对藻类、水蚤和斑马鱼胚胎的生态毒性评估，以及可生物降解性评估。选择唑类和苯并三唑类化合物进行测试，是基于对脊椎动物和无脊椎动物物种的现有毒性数据，以及针对分子描述符的主成分分析，目的是选择最少数量的测试化合物，以最大限度地扩大这两类化合物的化学领域。实验结果表明，唑类和苯并三唑类化合物在物种间的毒性差异相对较小；通常，最大的因素约为 20 倍。研究表明，唑类化合物不易生物降解。
