Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan.
Inhal Toxicol. 2013 Apr;25(5):298-306. doi: 10.3109/08958378.2013.780116.
Carcinogenicity of 1,1,1-trichloroethane (TCE) was examined by an inhalation exposure of F344 rats and BDF1 mice of both sexes to TCE at 0, 200, 800 or 3200 ppm for 6 h/d, 5 d/week for 104 weeks. In male rats, the incidences of bronchiolo-alveolar adenomas and peritoneal mesotheliomas were significantly increased in the 800 and 3200 ppm-exposed groups, respectively. The incidence of bronchiolo-alveolar adenomas in the 3200 ppm-exposed groups exceeded the range of historical control data in the Japan Bioassay Research Center. In female rats, the tumor incidences were not increased in any organs of the TCE-exposed groups. In male mice, a significant positive trend with dose was shown for incidences of bronchiolo-alveolar carcinomas, combined incidences of bronchiolo-alveolar adenomas/carcinomas and hepatocellular adenomas. The incidence of Harderian gland adenomas was significantly increased in the 3200 ppm-exposed group, and malignant lymphomas of spleen at this highest dose exceeded the range of historical control data. In female mice, the combined incidence of bronchiolo-alveolar adenomas/carcinomas was significantly increased in the 3200 ppm-exposed group, and the incidences of hepatocellular adenomas and combined incidences of hepatocellular adenomas/carcinomas were significantly increased in the 200, 800 and 3200 ppm-exposed groups with dose dependence except the combined incidence of hepatocellular adenomas/carcinomas in the 200 ppm-exposed group. The incidences of bronchiolo-alveolar adenomas in the 3200 ppm-exposed group and combined incidences of hepatocellular adenomas/carcinomas in the 200 ppm-exposed groups exceeded the ranges of historical control data. Thus, this study provided clear evidence of inhalation carcinogenicity for TCE in both rats and mice.
1,1,1-三氯乙烷（TCE）的致癌性通过 F344 大鼠和 BDF1 雌雄小鼠的吸入暴露进行了研究，这些动物在 104 周内，每天暴露于 0、200、800 或 3200ppm 的 TCE 中 6 小时/天，每周 5 天。在雄性大鼠中，分别在 800 和 3200ppm 暴露组中，支气管肺泡腺瘤和腹膜间皮瘤的发生率显著增加。在 3200ppm 暴露组中，支气管肺泡腺瘤的发生率超过了日本生物测定研究中心的历史对照数据范围。在雌性大鼠中，在任何 TCE 暴露组的器官中，肿瘤的发生率均未增加。在雄性小鼠中，支气管肺泡癌、支气管肺泡腺瘤/癌和肝细胞腺瘤的总发生率与剂量呈显著正相关趋势。在 3200ppm 暴露组中，哈德腺腺瘤的发生率显著增加，而在最高剂量下的脾恶性淋巴瘤超过了历史对照数据的范围。在雌性小鼠中，在 3200ppm 暴露组中，支气管肺泡腺瘤/癌的总发生率显著增加，而肝细胞腺瘤和肝细胞腺瘤/癌的总发生率在 200、800 和 3200ppm 暴露组中随着剂量的增加而显著增加，除了 200ppm 暴露组中肝细胞腺瘤/癌的总发生率外。在 3200ppm 暴露组中支气管肺泡腺瘤的发生率和在 200ppm 暴露组中肝细胞腺瘤/癌的总发生率超过了历史对照数据的范围。因此，本研究为 TCE 在大鼠和小鼠中的吸入致癌性提供了明确的证据。
