Ceschi Alessandro, Berger David, Dickenmann Michael, Bodmer Michael
Swiss Toxicological Information Centre, Associated Institute of the University of Zurich, Zurich, Switzerland.
Hemodial Int. 2013 Oct;17(4):656-9. doi: 10.1111/hdi.12047. Epub 2013 Apr 25.
We report a case of massive suicidal overdose of meprobamate leading to cardiovascular collapse, respiratory failure, and severe central nervous system depression. We observed first-order elimination kinetics despite significant overdose, and demonstrated effectiveness of continuous venovenous hemodiafiltration (CVVHDF) for extracorporeal removal of meprobamate in this patient. Total body clearance was calculated to be 87 mL/minute, with 64 mL/minute (74%) due to CVVHDF. CVVHDF was stopped after 36 hours, and the patient made an uneventful recovery.
我们报告了一例因大量自杀性过量服用眠尔通导致心血管衰竭、呼吸衰竭和严重中枢神经系统抑制的病例。尽管过量服用剂量很大，但我们观察到其符合一级消除动力学，并证明了连续性静脉-静脉血液透析滤过（CVVHDF）在此患者体外清除眠尔通的有效性。计算得出总体清除率为87毫升/分钟，其中CVVHDF的清除率为64毫升/分钟（占74%）。36小时后停止CVVHDF，患者顺利康复。
