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Gastrin-releasing peptide-expressing nerves comprise subsets of human cutaneous Aδ and C fibers that may sense pruritus.

作者信息

Timmes Theresa R, Rothbaum Robert, Silva Claudine Y, Bhawan Jag, Cummins Deborah L, Wolpowitz Deon

机构信息

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.

出版信息

J Invest Dermatol. 2013 Nov;133(11):2645-2647. doi: 10.1038/jid.2013.194. Epub 2013 Apr 23.

DOI:10.1038/jid.2013.194
PMID:23615431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3800262/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab5/3806245/b42305f45d84/jid2013194f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab5/3806245/b42305f45d84/jid2013194f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab5/3806245/b42305f45d84/jid2013194f1.jpg

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Overexpression of the gastrin-releasing peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch.在患有慢性瘙痒的灵长类动物中，皮肤神经纤维中胃泌素释放肽及其脊髓中受体的过表达。
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Non-myelinated C-fibers, but not myelinated A-fibers, elongate into the epidermis in dry skin with itch.无髓鞘的C纤维而非有髓鞘的A纤维，在伴有瘙痒的干性皮肤中会延伸至表皮。
Neurosci Lett. 2018 Apr 13;672:84-89. doi: 10.1016/j.neulet.2018.02.034. Epub 2018 Feb 21.
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Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice: an atopic dermatitis model.NC/Nga小鼠中含胃泌素释放肽的皮肤神经纤维的组织学特征：一种特应性皮炎模型
J Invest Dermatol. 2009 Dec;129(12):2901-5. doi: 10.1038/jid.2009.188. Epub 2009 Jul 2.
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Brain activation upon selective stimulation of cutaneous C- and Adelta-fibers.对皮肤C纤维和Aδ纤维进行选择性刺激时的脑激活情况。
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本文引用的文献

1
A subpopulation of nociceptors specifically linked to itch.与瘙痒特异性相关的伤害感受器亚群。
Nat Neurosci. 2013 Feb;16(2):174-82. doi: 10.1038/nn.3289. Epub 2012 Dec 23.
2
Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors.P 物质和胃泌素释放肽作为初级传入瘙痒感受器释放的神经递质的作用。
J Neurophysiol. 2013 Feb;109(3):742-8. doi: 10.1152/jn.00539.2012. Epub 2012 Nov 14.
3
The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons.
A neuropeptide code for itch.
一种神经肽编码瘙痒。
Nat Rev Neurosci. 2021 Dec;22(12):758-776. doi: 10.1038/s41583-021-00526-9. Epub 2021 Oct 18.
4
The Gastrin-Releasing Peptide Receptor (GRPR) in the Spinal Cord as a Novel Pharmacological Target.脊髓中的胃泌素释放肽受体（GRPR）作为一种新的药理学靶点。
Curr Neuropharmacol. 2014 Sep;12(5):434-43. doi: 10.2174/1570159X12666140923201432.
5
Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord.瘙痒相关肽：背根神经节、三叉神经节及脊髓中利钠肽前体B和胃泌素释放肽的RNA测序及生物信息学分析
Mol Pain. 2014 Aug 14;10:44. doi: 10.1186/1744-8069-10-44.
6
B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway.B 型利钠肽既非瘙痒特异性递质，也不在 GRP-GRPR 信号通路的上游发挥作用。
Mol Pain. 2014 Jan 18;10:4. doi: 10.1186/1744-8069-10-4.
大多数背根神经节胃泌素释放肽是局部合成的，而神经肽 B 在痛觉和痒觉感觉神经元中高度表达。
Mol Pain. 2012 Jul 9;8:52. doi: 10.1186/1744-8069-8-52.
4
Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease.疼痛和瘙痒：健康与疾病中厌恶触感觉神经回路的新见解。
Curr Opin Neurobiol. 2011 Dec;21(6):880-7. doi: 10.1016/j.conb.2011.10.012. Epub 2011 Nov 4.
5
A role for nociceptive, myelinated nerve fibers in itch sensation.伤害感受性、有髓神经纤维在痒觉中的作用。
J Neurosci. 2011 Oct 19;31(42):14841-9. doi: 10.1523/JNEUROSCI.3005-11.2011.
6
The multiple pathways for itch and their interactions with pain.瘙痒的多种途径及其与疼痛的相互作用。
Trends Neurosci. 2010 Dec;33(12):550-8. doi: 10.1016/j.tins.2010.09.002. Epub 2010 Nov 5.
7
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.伤害感受器中 VGLUT2 依赖性谷氨酸释放对于感知疼痛和抑制瘙痒是必需的。
Neuron. 2010 Nov 4;68(3):543-56. doi: 10.1016/j.neuron.2010.09.008.
8
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.TRPV1 群体中 VGLUT2 依赖性感觉神经元调节疼痛和瘙痒。
Neuron. 2010 Nov 4;68(3):529-42. doi: 10.1016/j.neuron.2010.09.016.
9
Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.感觉神经元特异性 G 蛋白偶联受体 Mrgprs 是介导氯喹诱导瘙痒的受体。
Cell. 2009 Dec 24;139(7):1353-65. doi: 10.1016/j.cell.2009.11.034. Epub 2009 Dec 10.
10
Cellular basis of itch sensation.瘙痒感觉的细胞基础。
Science. 2009 Sep 18;325(5947):1531-4. doi: 10.1126/science.1174868. Epub 2009 Aug 6.