Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, New York, NY, 10065, USA,
Clin Transl Oncol. 2013 Oct;15(10):759-65. doi: 10.1007/s12094-013-1041-1. Epub 2013 Apr 25.
A multi-modality approach that encompasses maximal surgical resection in combination with adjuvant therapy is critical for achieving optimal disease control in children with ependymoma. In view of its complex biology and variable response to therapy, ependymoma remains a challenge for clinicians involved in the care of these patients. Meanwhile, translation of molecular findings can characterize unique features of childhood ependymoma and their natural history. Furthermore, understanding the biology of pediatric ependymoma serves as a platform for development of future targeted therapies. In line with these goals, we review the molecular basis of pediatric ependymoma and its prognostic implications, as well as novel therapeutic advances in the management of ependymoma in children.
多模态方法包括最大限度的手术切除联合辅助治疗，对于实现儿童室管膜瘤的最佳疾病控制至关重要。鉴于其复杂的生物学特性和对治疗的不同反应，室管膜瘤仍然是参与这些患者治疗的临床医生面临的挑战。同时，分子研究结果的转化可以描述儿童室管膜瘤的独特特征及其自然病史。此外，了解儿童室管膜瘤的生物学特性为开发未来的靶向治疗提供了平台。基于这些目标，我们回顾了儿童室管膜瘤的分子基础及其预后意义，以及儿童室管膜瘤治疗方面的新的治疗进展。
