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当前儿科临床中的抗真菌药物。

Antifungal agents in current pediatric practice.

机构信息

Division of Pediatric Hematology and Oncology -Department of Hematology, Spirito Santo Hospital, Via Fonte Romana, Pescara, Italy,

出版信息

Curr Infect Dis Rep. 2013 Jun;15(3):278-87. doi: 10.1007/s11908-013-0337-1.

DOI:10.1007/s11908-013-0337-1
PMID:23616182
Abstract

Invasive fungal infections are an important cause of morbidity and mortality in immunocompromised children. Increases in the incidence of systemic mycoses have been observed during the last 2 decades. Treatment of invasive fungal infections has improved through a better knowledge and application of current treatment strategies and through the development of new antifungal compounds. The purpose of this review is to provide antifungal treatment recommendations for pediatric patients that can help clinicians find the most suitable treatment for each specific case.

摘要

侵袭性真菌感染是免疫功能低下儿童发病和死亡的重要原因。在过去的 20 年中,全身性真菌病的发病率有所增加。通过更好地了解和应用当前的治疗策略以及开发新的抗真菌药物,侵袭性真菌感染的治疗得到了改善。本文旨在为儿科患者提供抗真菌治疗建议,以帮助临床医生为每个具体病例找到最合适的治疗方案。

相似文献

1
Antifungal agents in current pediatric practice.当前儿科临床中的抗真菌药物。
Curr Infect Dis Rep. 2013 Jun;15(3):278-87. doi: 10.1007/s11908-013-0337-1.
2
Antifungal therapy in children: an update.儿童抗真菌治疗:更新。
Eur J Pediatr. 2013 Apr;172(4):437-46. doi: 10.1007/s00431-012-1758-9. Epub 2012 Jun 1.
3
New agents for invasive mycoses in children.
Curr Opin Pediatr. 2005 Feb;17(1):78-87. doi: 10.1097/01.mop.0000150630.83442.e1.
4
Current drug therapy of systemic mycoses: a review.系统性真菌病的当前药物治疗:综述
East Afr Med J. 1995 Jun;72(6):394-8.
5
Antifungal treatment in pediatric patients.儿科患者的抗真菌治疗。
Drug Resist Updat. 2005 Aug;8(4):235-45. doi: 10.1016/j.drup.2005.06.005. Epub 2005 Jul 27.
6
Current and future therapy of invasive fungal infections.侵袭性真菌感染的当前及未来治疗方法
Curr Clin Top Infect Dis. 1998;18:19-36.
7
Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants.预防性全身用抗真菌药物预防极低出生体重儿的死亡率和发病率。
Cochrane Database Syst Rev. 2013 Apr 30(4):CD003850. doi: 10.1002/14651858.CD003850.pub4.
8
Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants.预防性全身用抗真菌药物预防极低出生体重儿的死亡率和发病率。
Cochrane Database Syst Rev. 2007 Oct 17(4):CD003850. doi: 10.1002/14651858.CD003850.pub3.
9
Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.预防性口服/局部应用非吸收性抗真菌药物以预防极低出生体重儿侵袭性真菌感染。
Cochrane Database Syst Rev. 2013 Mar 28(3):CD003478. doi: 10.1002/14651858.CD003478.pub4.
10
Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.预防性口服/局部应用非吸收性抗真菌药物以预防极低出生体重儿侵袭性真菌感染。
Cochrane Database Syst Rev. 2015 Oct 24;2015(10):CD003478. doi: 10.1002/14651858.CD003478.pub5.

本文引用的文献

1
Treatment of cutaneous sporotrichosis with itraconazole--study of 645 patients.伊曲康唑治疗皮肤孢子丝菌病-645 例患者研究。
Clin Infect Dis. 2011 Jun 15;52(12):e200-6. doi: 10.1093/cid/cir245.
2
Echinocandin antifungal drugs in fungal infections: a comparison.棘白菌素类抗真菌药物治疗真菌感染:比较。
Drugs. 2011 Jan 1;71(1):11-41. doi: 10.2165/11585270-000000000-00000.
3
Retrospective survey on the off-label use of posaconazole in pediatric hematology patients.泊沙康唑在儿科血液病患者中未按药品说明书用药的回顾性调查。
Eur J Clin Microbiol Infect Dis. 2011 Apr;30(4):595-6. doi: 10.1007/s10096-010-1123-8. Epub 2010 Dec 1.
4
CHIT1 mutations: genetic risk factor for severe asthma with fungal sensitization?CHIT1 突变:真菌致敏性严重哮喘的遗传风险因素?
Pediatrics. 2010 Oct;126(4):e982-5. doi: 10.1542/peds.2010-0321. Epub 2010 Sep 6.
5
Update on antifungal agents for paediatric patients.儿科患者抗真菌药物的最新进展。
Clin Microbiol Infect. 2010 Sep;16(9):1343-53. doi: 10.1111/j.1469-0691.2010.03334.x.
6
Intra-abdominal Rhizopus microsporus infection successfully treated by combined aggressive surgical, antifungal, and iron chelating therapy.通过积极的手术、抗真菌和铁螯合联合治疗成功治愈腹腔内微小根毛霉感染。
J Pediatr Hematol Oncol. 2010 Aug;32(6):e238-40. doi: 10.1097/MPH.0b013e3181e622bf.
7
Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children.免疫功能低下儿童伏立康唑的药代动力学、安全性和耐受性。
Antimicrob Agents Chemother. 2010 Oct;54(10):4116-23. doi: 10.1128/AAC.00896-10. Epub 2010 Jul 26.
8
Guidelines for the management of tinea capitis in children.儿童头癣管理指南。
Pediatr Dermatol. 2010 May-Jun;27(3):226-8. doi: 10.1111/j.1525-1470.2010.01137.x.
9
Invasive aspergillosis in pediatric patients.儿童侵袭性曲霉病。
Curr Med Res Opin. 2010 Jul;26(7):1779-87. doi: 10.1185/03007995.2010.487793.
10
Candidemia in children.儿童念珠菌血症。
Curr Med Res Opin. 2010 Jul;26(7):1761-8. doi: 10.1185/03007995.2010.487796.