Normandie Université, France.
Carbohydr Polym. 2013 Jun 5;95(1):41-9. doi: 10.1016/j.carbpol.2013.02.032. Epub 2013 Feb 26.
The water soluble properties of different copolymers based on pullulan-block-polyetheramine have been deeply studied. The polyetheramine group (PEA) corresponding to a propylene oxyde/ethylene oxyde ratio (PO/EO) of 29/6, is condensed, via amine link, to pullulans with various chain lengths. Different polysaccharide/PEA (PS/PEA) ratio copolymers have been investigated through macroscopic (cloud point, enthalpy) and mesoscopic scale approaches (critical aggregation concentration (CAC), mean number average hydrodynamic diameter (Dh) or aggregation number (Nag)). These systems are both pH and/or thermo-sensitive. Finally, it seems that three states can describe such systems (i) isolated copolymers (unimers) below the CAC, (ii) water soluble aggregates above the CAC and whatever the PS/PEA ratio is due to hydrophobic interactions and (iii) non-soluble aggregates (above the critical temperature) due to dehydration of polyetheramine groups but only if PS/PEA ratio is low enough.
已经深入研究了基于普鲁兰-block-聚醚胺的不同共聚物的水溶性性质。聚醚胺基团（PEA）与丙烯氧化物/氧化乙烯比例（PO/EO）为 29/6 缩合，通过胺键与各种链长的普鲁兰连接。通过宏观（浊点、焓）和介观（临界聚集浓度（CAC）、平均数均水动力直径（Dh）或聚集数（Nag））方法研究了不同多糖/PEA（PS/PEA）比共聚物。这些系统均对 pH 和/或温度敏感。最后，似乎可以用三种状态来描述这些系统：（i）低于 CAC 的孤立共聚物（单体），（ii）无论 PS/PEA 比如何，由于疏水性相互作用，CAC 以上均为水溶性聚集体，以及（iii）由于聚醚胺基团的去水作用，但仅当 PS/PEA 比足够低时，非水溶性聚集体（高于临界温度）。
