Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Neurosci Lett. 2013 Jun 17;545:46-9. doi: 10.1016/j.neulet.2013.04.014. Epub 2013 Apr 22.
Multiple sclerosis (MS) is one of the most common neurological diseases of the central nervous system (CNS) which is mediated by the autoimmune reactions against myelin sheath. Both genetic and environmental factors are thought to be involved in the pathogenesis of MS. NF-κB1 is one of the most important molecules which regulates the immune functions. NF-κB1 -94 ins/del ATTG promoter polymorphism is a well-studied region in NF-κB1 gene associated with several common autoimmune diseases such as systemic lupus erythematosus (SLE). Our hypothesis was aimed to address the potential association of NF-κB polymorphism and MS. Therefore, we analyzed 200 sex and age matched MS patients along with 200 healthy individuals using PCR-RFLP. The data revealed no significant differences in the frequency of the -94 ins/del ATTG polymorphism in multiple sclerosis patients compared with the control group. To conclude, our study showed no association between -94 ins/del ATTG polymorphism and risk of multiple sclerosis in Iranian patients.
多发性硬化症（MS）是一种最常见的中枢神经系统（CNS）的神经疾病，由针对髓鞘的自身免疫反应引起。遗传和环境因素都被认为与 MS 的发病机制有关。NF-κB1 是调节免疫功能的最重要的分子之一。NF-κB1-94ins/del ATTG 启动子多态性是 NF-κB1 基因中一个研究得很好的区域，与几种常见的自身免疫性疾病有关，如系统性红斑狼疮（SLE）。我们的假设旨在探讨 NF-κB 多态性与 MS 的潜在关联。因此，我们使用 PCR-RFLP 分析了 200 名性别和年龄匹配的 MS 患者和 200 名健康个体。数据显示，多发性硬化症患者与对照组相比，-94ins/del ATTG 多态性的频率无显著差异。总之，我们的研究表明，伊朗患者中-94ins/del ATTG 多态性与多发性硬化症的风险之间没有关联。
