Department of Pathology and Cell Biology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
Curr Biol. 2013 Apr 22;23(8):R322-4. doi: 10.1016/j.cub.2013.03.005.
A recent paper has identified the tumor suppressor APC as a linker protein between intermediate filaments and microtubules. In the absence of APC, intermediate filaments collapse and the cells are no longer polarized and fail to migrate.
最近的一篇论文确定肿瘤抑制因子 APC 是中间丝和微管之间的连接蛋白。在没有 APC 的情况下，中间丝会崩溃，细胞不再极化，无法迁移。
