Arwatz G, Smits A J
Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
Biorheology. 2013;50(1-2):45-55. doi: 10.3233/BIR-130626.
We present measurements of human blood hemolysis caused by laminar shear stresses ranging from 50 to 500 Pa for exposure times extending from 60 to 300 s using a Taylor-Couette device. A viscoelastic model is proposed that captures the response of the red blood cells to shear stress. The model is based on well-established mechanical properties of the red blood cell membrane, and shows good agreement with data from the experiments presented here, as well as data from the existing literature. Two characteristic time scales are identified: a fast time scale corresponding to the relaxation time of the red blood cell membrane and a slow time scale that represents the onset of plasticity and is related to hemoglobin release from a damaged cell. The model proposed here collapses the available data over almost five orders of magnitude in exposure time and shear stresses up to 500 Pa.
我们展示了使用泰勒-库埃特装置，在50至500帕的层流剪切应力以及60至300秒的暴露时间下引起的人体血液溶血测量结果。提出了一个粘弹性模型，该模型能够捕捉红细胞对剪切应力的响应。该模型基于红细胞膜已确立的力学特性，并且与这里展示的实验数据以及现有文献中的数据显示出良好的一致性。确定了两个特征时间尺度：一个快速时间尺度对应于红细胞膜的弛豫时间，另一个缓慢时间尺度代表可塑性的开始并且与受损细胞中血红蛋白的释放有关。这里提出的模型将暴露时间和高达500帕的剪切应力下几乎五个数量级的现有数据整合在一起。
