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[淋巴管瘤——肾移植后的泌尿外科并发症]

[Lymphocele--urological complication after renal transplantation].

作者信息

Krajewski Wojciech, Piszczek Radosław, Weyde Wacław, Rybak Zbigniew, Dembowski Janusz

机构信息

Katedra i Klinika Urologii i Onkologii Urologicznej Uniwersytetu Medycznego, 50-556 Wrocław, Poland.

出版信息

Postepy Hig Med Dosw (Online). 2013 Apr 23;67:326-30. doi: 10.5604/17322693.1046281.

Abstract

Renal transplantation is the best renal replacement treatment. It provides longer survival and a better quality of life. The outcome of renal transplantation is influenced by the occurrence of various complications, including urological. One of the most frequently occurring complications is lymphocele. Most cases of lymphocele develop during a period of several weeks after the procedure of transplantation. However, there are some literature reports concerning lymphocele diagnosis in the later period, even after several years. Most cases of lymphocele are asymptomatic and are diagnosed accidentally. Nevertheless, a large lymphocele may press the kidney, ureter, urinary bladder or neighbouring blood vessels, causing deterioration of renal function, leg oedema and thrombosis of iliac vessels. Among other complications there are infections. The cause of lymphocele is collection of the lymph drained from damaged lymph vessels surrounding iliac blood vessels and/or lymph vessels of the graft. Important factors predisposing to lymphocele are immunosuppressive treatment, including mTOR inhibitors, mycophenolic acid derivatives and high doses of glucosteroids. Factors favouring occurrence of lymphocele comprise obesity, diabetes, elderly age of recipient, long time of warm ischaemia, acute rejection episodes and delayed graft function. The authors describe presently available treatment methods including aspiration and percutaneous drainage, with or without sclerotisation, drainage using the Tenckhoff catheter and laparoscopic or open fenestration. At present, laparoscopic fenestration is considered to be the most efficient and the safest method. However, there are clinical cases where open surgical treatment is necessary.

摘要

肾移植是最佳的肾脏替代治疗方法。它能带来更长的生存期和更高的生活质量。肾移植的结果会受到各种并发症的影响,包括泌尿系统并发症。最常见的并发症之一是淋巴囊肿。大多数淋巴囊肿病例在移植手术后的几周内形成。然而,也有一些文献报道了后期甚至数年后的淋巴囊肿诊断情况。大多数淋巴囊肿病例无症状,是偶然被诊断出来的。尽管如此,较大的淋巴囊肿可能会压迫肾脏、输尿管、膀胱或邻近血管,导致肾功能恶化、腿部水肿和髂血管血栓形成。其他并发症还包括感染。淋巴囊肿的成因是来自围绕髂血管和/或移植肾淋巴管的受损淋巴管引流的淋巴液积聚。导致淋巴囊肿的重要因素包括免疫抑制治疗,其中包括mTOR抑制剂、霉酚酸衍生物和高剂量糖皮质激素。有利于淋巴囊肿发生的因素包括肥胖、糖尿病、受者年龄较大、热缺血时间长、急性排斥反应发作和移植肾功能延迟。作者描述了目前可用的治疗方法,包括抽吸和经皮引流,有无硬化治疗、使用Tenckhoff导管引流以及腹腔镜或开放开窗术。目前,腹腔镜开窗术被认为是最有效和最安全的方法。然而,在一些临床病例中,开放手术治疗是必要的。

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