Mid Essex Hospitals Services NHS Trust, Department of Vascular Surgery, Broomfield Hospital, Essex CM1 7ET, UK.
Int J Surg. 2013;11(6):458-62. doi: 10.1016/j.ijsu.2013.04.008. Epub 2013 Apr 22.
There have been various suggestions that abdominal aortic aneurysm rupture (rAAA) might have a seasonal variation depending on atmospheric pressure (AP) alteration. Despite above suggestions no study has yet examined the effect of fluctuation in AP on daily, seasonal, monthly, AAA size and co-morbidities to reach a conclusive outcome.
A total of fifty (n = 50) ruptured AAA over a 5-year period were retrospectively studied. Local meteorological data on AP were obtained from UK Meteorological Office. The data was subjected to statistical analysis using Student's t-test, linear regression (Pearson correlation Coefficient) and Coefficient of determination to establish any casual link between AP and incidences of rAAA on daily, seasonal and monthly basis. The casual link was also assessed between AP, AAA size and co-morbidities. The outcome is presented in a format of comprehensive review of literature that detected only 6 papers in MEDLINE and EMBASE from 1951 to 2012 in UK.
There appears to be a significant correlation between mean monthly pressures and mean monthly rupture incidence (Pearson)(n = 12; r = -0.61; p < 0.034; rsq = 0.37). The periods of low AP are associated with higher incidence of rupture (rAAA n = 29 at mean atmospheric pressure 1012 mB Vs rAAA n = 12 at mean atmospheric pressure 1016 mB Vs rAAA n = 9 at mean atmospheric pressure of 1020 mB) in our study and all reviewed literature. In addition, no casual link between AP to co-morbidities (diabetes mellitus, hypertension ischaemic heart disease, chronic obstructive pulmonary disease) and AAA size could be established or found in the literature.
有各种说法认为，腹主动脉瘤破裂（rAAA）可能会随着大气压力（AP）的变化而呈现季节性变化。尽管有上述说法，但尚无研究检查 AP 的波动对每日、季节性、每月、AAA 大小和合并症的影响，以得出明确的结论。
回顾性研究了 5 年内总共 50 例破裂的 AAA。从英国气象局获得了关于 AP 的当地气象数据。使用学生 t 检验、线性回归（皮尔逊相关系数）和决定系数对数据进行统计分析，以确定 AP 与 rAAA 每日、季节性和每月发生之间是否存在因果关系。还评估了 AP、AAA 大小和合并症之间的因果关系。结果以文献综述的形式呈现，仅在英国的 MEDLINE 和 EMBASE 中从 1951 年到 2012 年检测到 6 篇论文。
平均每月压力与平均每月破裂发生率之间似乎存在显著相关性（皮尔逊）（n=12；r=-0.61；p<0.034；rsq=0.37）。在我们的研究和所有综述文献中，低 AP 期与破裂（rAAA n=29 在平均大气压 1012 mB V s rAAA n=12 在平均大气压 1016 mB V s rAAA n=9 在平均大气压 1020 mB）的发生率较高相关。此外，在文献中未发现 AP 与合并症（糖尿病、高血压缺血性心脏病、慢性阻塞性肺疾病）和 AAA 大小之间存在因果关系。
