Yamaki S, Ogata H, Haneda K, Mohri H
Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan.
Heart Vessels. 1990;5(3):166-71. doi: 10.1007/BF02059912.
In a previous paper, it was stated that open lung biopsy for determination of operative indications could be recommended if pulmonary vascular resistance (PVR) were higher than 8 units.m2 in patients with ventricular septal defect (VSD) and/or patent ductus arteriosus (PDA) with severe pulmonary hypertension. In the present study, oxygen inhalation or Tolazoline administration tests with or without occlusion of ductus arteriosus were performed during cardiac catheterization in 47 patients with VSD and/or PDA with severe pulmonary hypertension. The results obtained were compared with the operability based on our histopathological diagnostic criteria. There was no correlation between the oxygen, Tolazoline, or ductus occlusion hemodynamics and the baseline hemodynamics for better prediction of the biopsy should be performed for the determination of operative indication when patients with VSD and/or PDA have a PVR higher than 8 units.m2, and if the PVR is greater than 4 units.m2 with the oxygen inhalation test or 7 units.m2 with the Tolazoline test.
在之前的一篇论文中指出，对于患有室间隔缺损（VSD）和/或动脉导管未闭（PDA）且伴有严重肺动脉高压的患者，如果肺血管阻力（PVR）高于8单位·m²，可推荐进行开胸肺活检以确定手术指征。在本研究中，对47例患有VSD和/或PDA且伴有严重肺动脉高压的患者在心脏导管插入术期间进行了吸氧或妥拉唑啉给药试验，试验时动脉导管有或无封堵。将获得的结果与基于我们组织病理学诊断标准的可手术性进行比较。氧、妥拉唑啉或动脉导管封堵血流动力学与基线血流动力学之间无相关性，对于VSD和/或PDA患者，当PVR高于8单位·m²时，为确定手术指征应进行活检以更好地预测，如果吸氧试验时PVR大于4单位·m²或妥拉唑啉试验时PVR大于7单位·m²。
