癌症染色体走向 POT1。
Cancer chromosomes going to POT1.
机构信息
Department of Laboratory Medicine and Pathology at Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Nat Genet. 2013 May;45(5):473-5. doi: 10.1038/ng.2617.
Abstract
Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.
摘要
最近在慢性淋巴细胞白血病中发现了单链端粒结合蛋白 POT1 的改变。这一发现为端粒功能障碍引起的基因组不稳定性如何促进肿瘤发生提供了新的见解。
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本文引用的文献
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POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia.POT1 突变导致慢性淋巴细胞白血病中端粒功能障碍。
Nat Genet. 2013 May;45(5):526-30. doi: 10.1038/ng.2584. Epub 2013 Mar 17.
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