Department of Urology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
Jpn J Clin Oncol. 2013 Jul;43(7):734-9. doi: 10.1093/jjco/hyt060. Epub 2013 Apr 25.
We investigated the efficacy and toxicity of a docetaxel, ifosfamide and nedaplatin regimen as salvage therapy for patients with advanced testicular germ cell tumor.
Eleven patients with advanced germ cell tumor refractory or relapsed after cisplatin-based chemotherapy were treated using docetaxel, ifosfamide and nedaplatin. The docetaxel, ifosfamide and nedaplatin regimen comprised docetaxel (75 mg/m(2)) on Day 1, ifosfamide (2 g/m(2)) on Days 1-3 and nedaplatin (75 mg/m(2)) on Day 2 of a 3-week cycle.
Ten (91%) of the 11 patients achieved favorable responses, including complete response in one case and partial response in nine cases. Nine (81%) of the 11 patients have continued to show no evidence of disease after docetaxel, ifosfamide and nedaplatin therapy followed by subsequent surgical resection, with a median follow-up period of 52 months. One patient died of the disease 3 months after completing docetaxel, ifosfamide and nedaplatin chemotherapy. One patient was lost to follow-up with a status of alive with disease. Ten (91%) of the 11 patients developed Grade 4 leukopenia, which was managed using granulocyte colony-stimulating factor. No patients developed sensory neuropathy or renal dysfunction.
The docetaxel, ifosfamide and nedaplatin regimen was efficacious and well-tolerated as salvage chemotherapy for patients with advanced germ cell tumor.
我们研究了多西他赛、异环磷酰胺和奈达铂方案作为晚期睾丸生殖细胞肿瘤患者挽救性治疗的疗效和毒性。
11 例晚期生殖细胞肿瘤患者在接受顺铂为基础的化疗后出现耐药或复发，采用多西他赛、异环磷酰胺和奈达铂方案治疗。多西他赛、异环磷酰胺和奈达铂方案包括多西他赛（75mg/m²）第 1 天，异环磷酰胺（2g/m²）第 1-3 天，奈达铂（75mg/m²）第 2 天，每 3 周为 1 个周期。
11 例患者中，10 例（91%）获得了良好的反应，包括 1 例完全缓解和 9 例部分缓解。11 例患者中，9 例（81%）在接受多西他赛、异环磷酰胺和奈达铂治疗后继续无疾病证据，随后进行了手术切除，中位随访时间为 52 个月。1 例患者在完成多西他赛、异环磷酰胺和奈达铂化疗后 3 个月死于疾病。1 例患者失访，存活且有疾病。11 例患者中有 10 例（91%）发生 4 级白细胞减少症，使用粒细胞集落刺激因子治疗。无患者发生感觉神经病或肾功能不全。
多西他赛、异环磷酰胺和奈达铂方案作为晚期生殖细胞肿瘤的挽救性化疗方案是有效且耐受良好的。
