The Hospital for Sick Children, University of Toronto, Canada.
Mult Scler. 2013 Sep;19(10):1359-62. doi: 10.1177/1352458513486519. Epub 2013 Apr 25.
The 2010 McDonald criteria allow the diagnosis of multiple sclerosis (MS) at first attack in children and adults provided that the first attack symptoms are typical of MS and that the magnetic resonance imaging (MRI) conforms to prescribed features. We evaluate whether meeting the 2010 McDonald criteria at onset correlates with a more aggressive clinical course in a cohort of pediatric MS patients. The Expanded Disability Status Scale (EDSS) and annualized relapse rate were not associated with positivity for 2010 McDonald criteria at onset. The 2010 McDonald criteria identify children with similar MS features to those identified by clinical or MRI evidence of dissemination over time.
2010 年麦当劳标准允许在儿童和成人首次发作时诊断多发性硬化症（MS），前提是首次发作症状符合 MS 的典型特征，且磁共振成像（MRI）符合规定的特征。我们评估了在一组儿科 MS 患者中，首发时符合 2010 年麦当劳标准是否与更具侵袭性的临床病程相关。扩展残疾状况量表（EDSS）和年化复发率与首发时 2010 年麦当劳标准阳性无关。2010 年麦当劳标准识别出具有与随时间推移的临床或 MRI 证据扩散所识别的 MS 特征相似的儿童。
