Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Rheumatology (Oxford). 2013 Sep;52(9):1623-9. doi: 10.1093/rheumatology/ket158. Epub 2013 Apr 25.
We sought to examine primary care providers' gout knowledge and reported treatment patterns in comparison with current treatment recommendations.
We conducted a national survey of a random sample of US primary care physicians to assess their treatment of acute, intercritical and tophaceous gout using published European and American gout treatment recommendations and guidelines as a gold standard.
There were 838 respondents (response rate of 41%), most of whom worked in private practice (63%) with >16 years experience (52%). Inappropriate dosing of medications in the setting of renal disease and lack of prophylaxis when initiating urate-lowering therapy (ULT) accounted for much of the lack of compliance with treatment recommendations. Specifically for acute podagra, 53% reported avoidance of anti-inflammatory drugs in the setting of renal insufficiency, use of colchicine at a dose of ≤2.4 mg/day and no initiation of a ULT during an acute attack. For intercritical gout in the setting of renal disease, 3% would provide care consistent with the recommendations, including initiating a ULT at the appropriate dose with dosing titration to a serum urate level of ≤6 mg/dl and providing prophylaxis. For tophaceous gout, 17% reported care consistent with the recommendations, including ULT use with dosing titration to a serum urate level of ≤6 mg/dl and prophylaxis.
Only half of primary care providers reported optimal treatment practices for the management of acute gout and <20% for intercritical or tophaceous gout, suggesting that care deficiencies are common.
我们旨在研究初级保健提供者的痛风知识,并与当前的治疗建议进行比较,以评估他们的治疗急性、间歇期和痛风石性痛风的模式。
我们对美国初级保健医生进行了一项全国性的随机抽样调查,使用已发表的欧洲和美国痛风治疗建议和指南作为金标准,评估他们对急性、间歇期和痛风石性痛风的治疗方法。
共有 838 名受访者(响应率为 41%),他们大多在私人诊所工作(63%),经验超过 16 年(52%)。在存在肾脏疾病的情况下,药物剂量不当以及在开始降尿酸治疗(ULT)时缺乏预防措施,这在很大程度上导致了治疗建议的不遵守。具体来说,对于急性痛风性关节炎,53%的受访者报告在肾功能不全的情况下避免使用抗炎药物,使用秋水仙碱的剂量≤2.4mg/天,并且在急性发作期间不开始 ULT。对于存在肾脏疾病的间歇期痛风,只有 3%的受访者会提供符合建议的治疗,包括以适当剂量开始 ULT,并根据血清尿酸水平滴定剂量至≤6mg/dl,并提供预防措施。对于痛风石性痛风,17%的受访者报告提供符合建议的治疗,包括使用 ULT,并根据血清尿酸水平滴定剂量至≤6mg/dl,以及预防措施。
只有一半的初级保健提供者报告了治疗急性痛风的最佳治疗实践,而对于间歇期或痛风石性痛风,<20%的人报告了最佳治疗实践,这表明护理缺陷很常见。