• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

慢性髓性白血病(CML)药物的价格反映了癌症药物的不可持续价格:从一大群 CML 专家的角度来看。

The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts.

出版信息

Blood. 2013 May 30;121(22):4439-42. doi: 10.1182/blood-2013-03-490003. Epub 2013 Apr 25.

DOI:10.1182/blood-2013-03-490003
PMID:23620577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4190613/
Abstract

As a group of more than 100 experts in chronic myeloid leukemia (CML), we draw attention to the high prices of cancer drugs, with the particular focus on the prices of approved tyrosine kinase inhibitors for the treatment of CML. This editorial addresses the multiple factors involved in cancer drug pricing and their impact on individual patients and health care policies, and argues for the need to (1) lower the prices of cancer drugs to allow more patients to afford them and (2) maintain sound long-term health care policies.

摘要

作为一个由 100 多名慢性髓性白血病(CML)专家组成的团队,我们提请大家注意癌症药物的高价格,特别是已批准的用于治疗 CML 的酪氨酸激酶抑制剂的价格。本社论讨论了癌症药物定价涉及的多个因素及其对个体患者和医疗保健政策的影响,并主张需要(1)降低癌症药物的价格,以使更多的患者能够负担得起这些药物,以及(2)维持健全的长期医疗保健政策。

相似文献

1
The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts.慢性髓性白血病(CML)药物的价格反映了癌症药物的不可持续价格:从一大群 CML 专家的角度来看。
Blood. 2013 May 30;121(22):4439-42. doi: 10.1182/blood-2013-03-490003. Epub 2013 Apr 25.
2
Pricing Cancer Drugs: When Does Pricing Become Profiteering?癌症药物定价:定价何时变成暴利?
AMA J Ethics. 2015 Aug 1;17(8):750-3. doi: 10.1001/journalofethics.2015.17.8.nlit1-1508.
3
Cost-effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase After Generic Entry of Imatinib in the United States.伊马替尼在美国进入仿制药市场后,酪氨酸激酶抑制剂治疗慢性粒细胞白血病慢性期策略的成本效益
J Natl Cancer Inst. 2016 Mar 4;108(7). doi: 10.1093/jnci/djw003. Print 2016 Jul.
4
Treatment value of second-generation BCR-ABL1 tyrosine kinase inhibitors compared with imatinib to achieve treatment-free remission in patients with chronic myeloid leukaemia: a modelling study.与伊马替尼相比,第二代BCR-ABL1酪氨酸激酶抑制剂在慢性髓性白血病患者中实现无治疗缓解的治疗价值:一项建模研究
Lancet Haematol. 2019 Aug;6(8):e398-e408. doi: 10.1016/S2352-3026(19)30087-0. Epub 2019 Jun 14.
5
Generics in chronic myeloid leukemia: current arguments for and against and the established evidence.慢性髓性白血病中的仿制药:支持与反对的当前论据及既有证据
Expert Rev Hematol. 2014 Dec;7(6):697-9. doi: 10.1586/17474086.2014.966679. Epub 2014 Oct 8.
6
The value of open access and a patient centric approach to oral oncolytic utilization in the treatment of Chronic Myelogenous Leukemia: A U.S. perspective.开放获取以及以患者为中心的方法在慢性粒细胞白血病治疗中应用口腔溶瘤疗法的价值:美国视角
Expert Rev Pharmacoecon Outcomes Res. 2017 Apr;17(2):133-140. doi: 10.1080/14737167.2017.1305892. Epub 2017 Mar 22.
7
Indian patients go to court over cancer drug.印度患者就抗癌药物问题诉诸法庭。
BMJ. 2004 Aug 21;329(7463):419. doi: 10.1136/bmj.329.7463.419.
8
Cost-effectiveness of dasatinib versus high-dose imatinib in patients with Chronic Myeloid Leukemia (CML), resistant to standard dose imatinib--a Swedish model application.达沙替尼与高剂量伊马替尼治疗对标准剂量伊马替尼耐药的慢性髓性白血病(CML)患者的成本效益:瑞典模型应用。
Acta Oncol. 2010 Aug;49(6):851-8. doi: 10.3109/0284186X.2010.495132.
9
Generic imatinib in the treatment of chronic myeloid leukemia: two years' experience in Latvia.通用型伊马替尼治疗慢性髓性白血病:拉脱维亚的两年经验。
Exp Oncol. 2017 Jul;39(2):151-154.
10
Having "Skin in the Game" and Allowing Cross-Border Importation of Drugs to Lower High Prices of Cancer Drugs.让自身利益相关并允许药品跨境进口以降低抗癌药物的高昂价格。
JAMA Oncol. 2015 Sep;1(6):729-30. doi: 10.1001/jamaoncol.2015.1024.

引用本文的文献

1
The Political Economy of the World Health Organization Model Lists of Essential Medicines.世界卫生组织基本药物示范清单的政治经济学
Milbank Q. 2025 Mar;103(1):52-99. doi: 10.1111/1468-0009.70001. Epub 2025 Feb 27.
2
Ethyl Acetate Extract from Romdoul () Fruit Induced Apoptosis in Human Promyelocytic Leukemia Cells.罗姆杜尔()果实的乙酸乙酯提取物诱导人早幼粒细胞白血病细胞凋亡。 需注意,原文中“Romdoul ()”括号部分内容缺失,翻译可能会因信息不完整存在一定局限性。
Glob Adv Integr Med Health. 2024 Oct 23;13:27536130241296826. doi: 10.1177/27536130241296826. eCollection 2024 Jan-Dec.
3
Treatment-free remission after discontinuation of tyrosine kinase inhibitors in patients with chronic myeloid leukemia in the chronic phase: a systematic review and meta-analysis.慢性期慢性髓性白血病患者停用酪氨酸激酶抑制剂后的无治疗缓解:一项系统评价和荟萃分析。
Discov Oncol. 2024 Oct 23;15(1):586. doi: 10.1007/s12672-024-01444-9.
4
Asciminib, a novel allosteric inhibitor of BCR-ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance.ASCIMIB,一种新型的 BCR-ABL1 变构抑制剂,与伊马替尼联合使用时具有协同作用,无论是否存在耐药性。
Pharmacol Res Perspect. 2024 Aug;12(4):e1214. doi: 10.1002/prp2.1214.
5
Myeloproliferative neoplasms in the adolescent and young adult population: A comprehensive review of the literature.青少年和年轻成人人群中的骨髓增殖性肿瘤:文献综述。
Br J Haematol. 2024 Jul;205(1):48-60. doi: 10.1111/bjh.19557. Epub 2024 Jun 10.
6
Treatment-Free Remission in Chronic Myeloid Leukemia.慢性髓性白血病的无治疗缓解
J Clin Med. 2024 Apr 27;13(9):2567. doi: 10.3390/jcm13092567.
7
Financial difficulties experienced by patients with gastrointestinal stromal tumours (GIST) in the Netherlands: data from a cross-sectional multicentre study.荷兰胃肠道间质瘤(GIST)患者的经济困难:一项横断面多中心研究的数据。
Support Care Cancer. 2024 Apr 10;32(5):279. doi: 10.1007/s00520-024-08451-0.
8
The Application of Artificial Intelligence and Drug Repositioning for the Identification of Fibroblast Growth Factor Receptor Inhibitors: A Review.人工智能与药物重定位在成纤维细胞生长因子受体抑制剂识别中的应用:综述
Adv Biomed Res. 2024 Jan 30;13:9. doi: 10.4103/abr.abr_170_23. eCollection 2024.
9
An unusual ionic cocrystal of ponatinib hydrochloride: characterization by single-crystal X-ray diffraction and ultra-high field NMR spectroscopy.一种不同寻常的盐酸普纳替尼离子共晶体:通过单晶X射线衍射和超高场核磁共振光谱进行表征
CrystEngComm. 2024 Jan 30;26(9):1219-1233. doi: 10.1039/d3ce01062g. eCollection 2024 Feb 27.
10
The Contemporary Role of Hematopoietic Stem Cell Transplantation in the Management of Chronic Myeloid Leukemia: Is It the Same in All Settings?造血干细胞移植在慢性髓性白血病治疗中的当代作用:在所有情况下都相同吗?
Cancers (Basel). 2024 Feb 12;16(4):754. doi: 10.3390/cancers16040754.

本文引用的文献

1
Trends in chronic myeloid leukemia incidence and survival in the United States from 1975 to 2009.美国 1975 年至 2009 年慢性髓性白血病发病和生存趋势。
Leuk Lymphoma. 2013 Jul;54(7):1411-7. doi: 10.3109/10428194.2012.745525. Epub 2012 Dec 5.
2
Cost control in a parallel universe: Medicare spending in the United States and Canada.平行世界中的成本控制:美国和加拿大的医疗保险支出
Arch Intern Med. 2012 Dec 10;172(22):1764-6. doi: 10.1001/2013.jamainternmed.272.
3
Pharmaceutical research and development: what do we get for all that money?药物研发:我们投入那么多资金,收获了什么?
BMJ. 2012 Aug 7;345:e4348. doi: 10.1136/bmj.e4348.
4
Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy.酪氨酸激酶抑制剂治疗时代慢性髓性白血病发病率的增长和平台期发病率的估计。
Cancer. 2012 Jun 15;118(12):3123-7. doi: 10.1002/cncr.26679. Epub 2012 Jan 31.
5
Success story of targeted therapy in chronic myeloid leukemia: a population-based study of patients diagnosed in Sweden from 1973 to 2008.慢性髓性白血病靶向治疗的成功案例:1973 年至 2008 年在瑞典诊断的患者的基于人群的研究。
J Clin Oncol. 2011 Jun 20;29(18):2514-20. doi: 10.1200/JCO.2011.34.7146. Epub 2011 May 16.
6
Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib.多中心独立评估伊马替尼治疗慢性髓性白血病患者的结局。
J Natl Cancer Inst. 2011 Apr 6;103(7):553-61. doi: 10.1093/jnci/djr060. Epub 2011 Mar 21.
7
An empiric estimate of the value of life: updating the renal dialysis cost-effectiveness standard.生命价值的经验性估计:更新肾透析的成本效益标准。
Value Health. 2009 Jan-Feb;12(1):80-7. doi: 10.1111/j.1524-4733.2008.00401.x.
8
How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question.生命价值几何:西妥昔单抗、非小细胞肺癌与那4400亿美元的问题
J Natl Cancer Inst. 2009 Aug 5;101(15):1044-8. doi: 10.1093/jnci/djp177. Epub 2009 Jun 29.
9
Medical bankruptcy in the United States, 2007: results of a national study.2007年美国的医疗破产:一项全国性研究的结果
Am J Med. 2009 Aug;122(8):741-6. doi: 10.1016/j.amjmed.2009.04.012. Epub 2009 Jun 6.
10
Efficacy does not necessarily translate to cost effectiveness: a case study in the challenges associated with 21st-century cancer drug pricing.疗效不一定等同于成本效益:一项关于21世纪癌症药物定价相关挑战的案例研究。
J Clin Oncol. 2009 May 1;27(13):2111-3. doi: 10.1200/JCO.2008.21.0534. Epub 2009 Mar 30.