Bailey J A, Brown L S
Division of Evaluation and Medical Affairs, Addiction Research and Treatment Corporation, Brooklyn, NY 11201.
J Natl Med Assoc. 1990 Jun;82(6):405-8.
Human immunodeficiency virus (HIV) infection continues to be a major health problem for society. Intravenous drug users are the second largest risk group for HIV infection. The disease primarily affects immunologic functioning. This study examined the inherent immunologic dysfunction by measuring the seroprevalence of infection against pathogens often associated with HIV infection. Additionally, chi square analysis was used to compare intravenous drug users with a non-drug-using control group to see if any difference existed in the prevalence of antinuclear antibody, rheumatoid factor, abnormal titer of antibody to Toxoplasma gondii, cytomegalovirus, and herpes simplex virus (types 1 and 2). The intravenous drug users had a significantly greater level of antibody titers for antinuclear antibody and Toxoplasma gondii than did controls. Abnormal serologic results were not significantly associated with HIV seropositivity. The findings of this study suggest that intravenous drug users experience a greater prevalence of alteration in serologic markers unrelated to HIV exposure.
人类免疫缺陷病毒（HIV）感染仍然是社会面临的一个主要健康问题。静脉吸毒者是HIV感染的第二大风险群体。该疾病主要影响免疫功能。本研究通过测量针对通常与HIV感染相关的病原体的感染血清阳性率来检查内在的免疫功能障碍。此外，使用卡方分析比较静脉吸毒者与非吸毒对照组，以观察抗核抗体、类风湿因子、弓形虫抗体滴度异常、巨细胞病毒和单纯疱疹病毒（1型和2型）的患病率是否存在差异。静脉吸毒者的抗核抗体和弓形虫抗体滴度水平明显高于对照组。血清学异常结果与HIV血清阳性无显著相关性。本研究结果表明，静脉吸毒者血清学标志物改变的患病率更高，且这些改变与HIV暴露无关。
