Yasuda S, Hiyama A, Shigematsu T, Kaneko S, Miyazawa N, Tabuchi H, Toyoda Y, Tatara T
Department of Anesthesia, Tokyo Metropolitan Ohtsuka Hospital.
Masui. 1990 Apr;39(4):487-90.
In three groups [(1) intravenous buprenorphine (0.1mg) or (2) fentanyl (100 micrograms.hr-1) and (3) epidural injection of buprenorphine (0.1mg diluted with 10ml normal saline)], we determined the effects of postoperative pain relief in patients after upper abdominal surgery. There are no differences in postoperative analgesia in the three groups, but respiratory depression was seen in some patients who had intravenous buprenorphine or fentanyl. We conclude that epidural injection of buprenorphine is a useful method for postoperative analgesia because of little adverse effect. As respiratory depression caused by buprenorphine was reversed with naloxone, it is not necessary to employ fentanyl instead of buprenorphine.
在三组中（(1)静脉注射丁丙诺啡（0.1毫克）或(2)芬太尼（100微克·小时-1）以及(3)硬膜外注射丁丙诺啡（0.1毫克用10毫升生理盐水稀释）），我们测定了上腹部手术后患者的术后疼痛缓解效果。三组在术后镇痛方面没有差异，但在接受静脉注射丁丙诺啡或芬太尼的一些患者中出现了呼吸抑制。我们得出结论，硬膜外注射丁丙诺啡是一种有用的术后镇痛方法，因为不良反应较少。由于丁丙诺啡引起的呼吸抑制可用纳洛酮逆转，因此没有必要用芬太尼替代丁丙诺啡。
