Matsuda M, Ohguro N, Ishimoto I, Fukuda M
Department of Ophthalmology, Osaka University Medical School, Japan.
Jpn J Ophthalmol. 1990;34(1):53-6.
Using specular microscopy and computer-assisted morphometry, the morphologic features of the corneal endothelium were evaluated in three groups of patients with type II diabetes mellitus: 20 patients without diabetic retinopathy, 24 with background retinopathy, and 26 with proliferative retinopathy. When compared to age-matched nondiabetic controls (30 patients), all diabetic groups had similar endothelial cell densities but demonstrated significant increases in cell size and shape variability (pleomorphism). However, there was no significant difference in the degree of these endothelial changes among the three diabetic groups. Moreover, none of the endothelial morphologic parameters was found to correlate with the duration of diabetes or glycemic control, as estimated from glycosylated hemoglobin (HbA1) concentrations.
利用镜面显微镜检查和计算机辅助形态测量法，对三组II型糖尿病患者的角膜内皮形态特征进行了评估：20例无糖尿病视网膜病变患者、24例有背景性视网膜病变患者和26例有增殖性视网膜病变患者。与年龄匹配的非糖尿病对照组（30例患者）相比，所有糖尿病组的内皮细胞密度相似，但细胞大小和形状变异性（多形性）显著增加。然而，这三组糖尿病患者之间内皮细胞变化的程度没有显著差异。此外，未发现任何内皮形态学参数与糖尿病病程或糖化血红蛋白（HbA1）浓度所估计的血糖控制情况相关。
