Centre for Infection and Immunity, Division of Clinical Sciences, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Trends Parasitol. 2013 Jul;29(7):313-7. doi: 10.1016/j.pt.2013.04.001. Epub 2013 Apr 25.
The definition of artemisinin resistance is becoming one of a prolonged parasite clearance phenotype, although this variable is a complex function of both host and parasite characteristics. We discuss some of the limitations of this definition of artemisinin resistance, particularly because of its potential global impact. This opinion article reviews the mechanisms underlying parasite clearance after artemisinin treatment and how these might relate to in vitro methods to assay for resistance. It revisits criteria for defining artemisinin resistance that are not currently being applied and suggests the term 'treatment failure of artemisinin combination therapy' (TFACT) as a more accurate description of most cases of 'artemisinin resistance'.
青蒿素耐药性的定义正在成为一种寄生虫清除表型的延长，尽管这种可变性是宿主和寄生虫特征的复杂函数。我们讨论了该青蒿素耐药性定义的一些局限性，特别是因为其潜在的全球影响。本文回顾了青蒿素治疗后寄生虫清除的机制，以及这些机制如何与体外检测耐药性的方法相关。它重新审视了目前未应用的青蒿素耐药性定义标准，并提出“青蒿素联合疗法治疗失败”（TFACT）一词作为大多数“青蒿素耐药性”病例的更准确描述。
