Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, No. 2, Linggong Rd., Dalian 116024, China.
Math Biosci. 2013 Jul;244(1):47-57. doi: 10.1016/j.mbs.2013.04.005. Epub 2013 Apr 26.
Regulation of intracellular calcium ion concentration ([Ca(2+)]in) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca(2+) influx via voltage-gated Ca(2+) channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca(2+)]in dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca(2+)]in predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca(2+) response but also a quantitative way to regulate the [Ca(2+)]in dynamics by controlling the external electrical stimulation.
细胞外电刺激诱导成纤维细胞内钙离子浓度 ([Ca(2+)]in) 的调节可用于有选择性地控制基因表达，进而调节成纤维细胞的功能。关于成纤维细胞中电压门控钙离子通道和/或牵张激活阳离子通道介导的电场诱导 Ca(2+)内流的机制，提出了一个动态数学模型来量化直流或交流电场作用下 [Ca(2+)]in 的动力学变化。模拟结果表明，我们的动态模型预测的 [Ca(2+)]in 变化与文献中的实验数据一致。所提出的动态模型不仅可以更深入地了解电场诱导的细胞内 Ca(2+)反应，还可以通过控制外部电刺激来定量调节 [Ca(2+)]in 的动力学。
