Washington Cancer Institute, MedStar Washington Hospital Center, Washington, District of Columbia 20010, USA.
Oncologist. 2013;18(5):490-2. doi: 10.1634/theoncologist.2013-0094. Epub 2013 Apr 26.
Trastuzumab is now the standard of care for metastatic and early breast cancer; however, questions remain regarding the optimal schedule of trastuzumab in the adjuvant setting. This commentary discusses the results from recent clinical trials with regard to the optimal duration of trastuzumab treatment, as well as the benefits of providing trastuzumab sequentially versus concurrently to chemotherapy.
曲妥珠单抗现已成为转移性和早期乳腺癌的标准治疗方法;然而,在辅助治疗环境中,曲妥珠单抗的最佳方案仍存在疑问。本评论讨论了最近临床试验中关于曲妥珠单抗治疗最佳持续时间的结果,以及与化疗序贯或同时使用曲妥珠单抗的益处。