Department of Rehabilitation Medicine, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
J Rehabil Med. 2013 Jun;45(6):587-94. doi: 10.2340/16501977-1146.
To describe changes in health-related quality of life in people with lower limb amputation, from time of amputation to 18 months, taking into consideration the influence of age and walking distance. In addition, quality of life for people with amputation is compared with the Dutch population norm values.
Multicentre, longitudinal study.
All people undergoing first amputation: 106 were referred, of whom 82 were included, mean age 67.8 years (standard deviation; SD 13.0), 67% men. A total of 35 remained in the study at 18 months.
Dutch language RAND-36 questionnaire (Research and Development Corporation measure of Quality of Life) was completed at time of amputation, 6 and 18 months after amputation.
Over time, a significant improvement was seen in physical function, social function, pain, vitality, and perceived change in health (all p < 0.001). Subjects over 65 years of age had a poorer outcome compared with people <65 years for physical function only (p < 0.001). Walking distance was associated with improved scores in social function (p = 0.047).
Quality of life improved significantly in 5 of 7 domains investigated; most change occurred in the first 6 months. Physical function remained well below population norm values. Different domains may be affected in different ways for older and younger age groups, but this requires further research.
描述下肢截肢患者从截肢到 18 个月的健康相关生活质量变化，同时考虑年龄和步行距离的影响。此外，还将比较截肢患者的生活质量与荷兰人群的标准值。
多中心、纵向研究。
所有初次截肢者：共转诊 106 例，其中 82 例纳入，平均年龄 67.8 岁（标准差；SD 13.0），67%为男性。共有 35 例在 18 个月时仍在研究中。
使用荷兰语 RAND-36 问卷（Research and Development Corporation 生活质量衡量标准）在截肢时、截肢后 6 个月和 18 个月进行评估。
随着时间的推移，身体功能、社会功能、疼痛、活力和对健康变化的感知都有显著改善（均 p<0.001）。年龄在 65 岁以上的受试者与年龄在 65 岁以下的受试者相比，身体功能的结果更差（p<0.001）。步行距离与社会功能的改善呈正相关（p=0.047）。
7 个调查领域中有 5 个领域的生活质量显著改善；大多数变化发生在最初的 6 个月内。身体功能仍远低于人群的标准值。不同年龄组的不同领域可能受到不同的影响，但这需要进一步的研究。
