原花青素 B6 的首次区域控制合成，一种具有罕见连接方式的儿茶素二聚体：形成 4,6-间黄烷键的卤帽策略。
First regiocontrolled synthesis of procyanidin B6, a catechin dimer with rare connectivity: a halo-capping strategy for formation of 4,6-interflavan bonds.
机构信息
Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
出版信息
Chem Commun (Camb). 2013 Jun 7;49(45):5210-2. doi: 10.1039/c3cc41993b.
PMID:23625307
Abstract
The first regiocontrolled synthesis of procyanidin B6, a dimer with a rare 4,6-interflavan linkage, is described. Regioselective linking was achieved by the halo-capping strategy followed by removal of all the benzyl protecting groups and the halo-caps by one-pot hydrogenolysis.
摘要
首次实现了原花青素 B6（一种具有罕见 4,6-间黄烷键的二聚体）的区域控制立体选择性合成。通过卤帽策略实现区域选择性连接，然后通过一锅氢解同时去除所有苄基保护基和卤帽。
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