Krepler P, Windhager R
Medizinische Universität Wien, Universitätsklinik für Orthopädie.
Z Orthop Unfall. 2013 Apr;151(2):e1-9; quiz e10. doi: 10.1055/s-0032-1328464. Epub 2013 Apr 26.
Spinal metastases occur in 10 % of all carcinoma patients in the course of their oncologic disease. Spinal metastasis is a manifestation of a systemic oncologic disease. The treatment of the metastasis does not influence the overall oncological outcome. Treatment decision is depending from the primary tumor, presence of neurological symptoms, stability of the spine, extent of visceral and osseous dissemination, general state of the patient and his life expectancy. Therapy should focus on the patient's needs and be correlated with the expectations and prognosis of the patient. There exist a number of valid prognostic scores to support and objectify the decision. There has been a change of paradigmata with regard to surgical treatment, supported by an improvement in oncosurgical and anesthesiological fields. Surgery is indicated in case of instability or neurological compromise, in respect of the general state and life expectancy and can be performed from a ventral, dorsal or combined approach. Alternative or complimentary treatment methods are radiotherapy, chemotherapy, hormonotherapy, stereotactic radiosurgery and additive therapies like sequential embolization, antiresorptive medication or corticoid therapy. Therapy should be established by a multidisciplinary tumor board. Main issue for treatment decisions is palliation and optimizing the patient's quality of life.
在所有癌症患者的肿瘤疾病过程中,脊柱转移的发生率为10%。脊柱转移是全身性肿瘤疾病的一种表现。转移灶的治疗并不影响总体肿瘤治疗结果。治疗决策取决于原发肿瘤、神经症状的存在、脊柱的稳定性、内脏和骨转移的范围、患者的一般状况及其预期寿命。治疗应关注患者的需求,并与患者的期望和预后相关。有许多有效的预后评分来支持并使决策客观化。在肿瘤外科和麻醉领域的进步支持下,手术治疗的模式发生了变化。在存在不稳定或神经功能损害的情况下,根据患者的一般状况和预期寿命,手术是可行的,可通过前路、后路或联合入路进行。替代或辅助治疗方法包括放疗、化疗、激素治疗、立体定向放射外科以及诸如序贯栓塞、抗吸收药物或皮质类固醇治疗等附加疗法。治疗应由多学科肿瘤委员会制定。治疗决策的主要问题是缓解症状并优化患者的生活质量。