Department of Neurology, University at Buffalo, Buffalo General Medical Center, 100 High Street, Buffalo, New York 14203-1126, USA.
Muscle Nerve. 2013 Jun;47(6):805-15. doi: 10.1002/mus.23755. Epub 2013 Apr 29.
Neuromuscular clinicians are frequently asked to evaluate patients referred for asymptomatic elevations in creatine kinase (CK), a catalytic enzyme that combines creatine and ATP to form phosphocreatine and ADP. This reaction is crucial for cellular energy generation and metabolism. This laboratory finding, often referred to in simplified lexicon as asymptomatic hyperCKemia, continues to generate controversy at several levels, including definition, the extent of evaluation, and the yield of diagnostic testing. In this review, we summarize the literature based on series of patients with asymptomatic hyperCKemia and provide a rational clinical approach to reveal identifiable underlying causes.
神经肌肉临床医生经常被要求评估因肌酸激酶 (CK) 升高而就诊的无症状患者，CK 是一种催化酶，可将肌酸与 ATP 结合形成磷酸肌酸和 ADP。该反应对细胞能量生成和代谢至关重要。这种实验室发现，通常在简化词汇中称为无症状高肌酸激酶血症，在多个层面上继续引起争议，包括定义、评估程度和诊断测试的结果。在这篇综述中，我们根据一系列无症状高肌酸激酶血症患者的系列研究总结了文献，并提供了一种合理的临床方法来揭示可识别的潜在原因。
