Laboratory of Pathological Cell Biology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.
J Biochem. 2013 Jun;153(6):505-10. doi: 10.1093/jb/mvt034. Epub 2013 Apr 26.
Cells internalize extracellular solutes, ligands and proteins and lipids in the plasma membrane (PM) by endocytosis. The removal of membrane from the PM is counteracted by endosomal recycling pathways that return the endocytosed proteins and lipids back to the PM. Recycling to the PM can occur from early endosomes. However, many cells have a distinct subpopulation of endosomes that have a mildly acidic pH of 6.5 and are involved in the endosomal recycling. These endosomes are dubbed recycling endosomes (REs). In recent years, studies have begun to reveal that function of REs is not limited to the endosomal recycling. In this review, I summarize the nature of membrane trafficking pathways that pass through REs and the cell biological roles of these pathways.
细胞通过内吞作用将细胞外的溶质、配体和蛋白质以及质膜（PM）中的脂质内化。内体回收途径会抵消从 PM 中去除膜的作用，这些途径将内吞的蛋白质和脂质返回 PM。从早期内体可以进行回收至 PM。然而，许多细胞具有一种独特的内体亚群，其 pH 值为 6.5，并且参与内体的再循环。这些内体被称为再循环内体（RE）。近年来，研究开始揭示 RE 的功能不仅限于内体再循环。在这篇综述中，我总结了通过 RE 的膜运输途径的性质以及这些途径的细胞生物学作用。
