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高尔基/内质网单位的全细胞排列取决于微管组织。

Cell-wide arrangement of Golgi/RE units depends on the microtubule organization.

机构信息

Program of Life and Environmental Science, Graduate School of Integral Science for Life, Hiroshima University.

Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University.

出版信息

Cell Struct Funct. 2024 Nov 7;49(2):101-110. doi: 10.1247/csf.24055. Epub 2024 Oct 3.

DOI:10.1247/csf.24055
PMID:39358226
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11930777/
Abstract

We have previously shown that Golgi stacks and recycling endosomes (REs) exist as Golgi/RE units in sea urchin embryos. In this study, we showed that Golgi/RE units were scattered throughout the cytoplasm at early developmental stages but gathered to form a "Golgi ring" surrounding the centric REs at the blastula stage. This change in the cell-wide arrangement of Golgi/RE units coincided with a dramatic change in microtubule organization from a randomly oriented cortical pattern to radial arrays under the apical plasma membrane. A single gigantic Golgi apparatus surrounding centric RE is clearly associated with the center of the radial microtubule arrays. Furthermore, we found that in some animal species belonging to different clades, Golgi stacks lack lateral connections but are likely centralized by microtubule motors. These results suggest that Golgi centralization depends on the organization of the microtubule array in addition to the lateral linking between Golgi stacks.Key words: Golgi stack, recycling endosome, Golgi-ribbon, microtubule, cilium, sea urchin, ascidian.

摘要

我们之前已经表明，高尔基堆叠和再循环内体（REs）在海胆胚胎中作为高尔基/RE 单元存在。在这项研究中，我们表明高尔基/RE 单元在早期发育阶段散布在细胞质中，但在原肠胚阶段聚集形成一个围绕中心 RE 的“高尔基环”。高尔基/RE 单元在细胞范围内的这种排列变化与微管组织的剧烈变化同时发生，从随机定向的皮质模式转变为顶端质膜下的放射状排列。一个围绕中心 RE 的单一巨大高尔基器显然与放射状微管阵列的中心相关。此外，我们发现，在属于不同进化枝的一些动物物种中，高尔基堆叠缺乏侧向连接，但可能被微管马达集中。这些结果表明，高尔基集中化不仅取决于高尔基堆叠之间的侧向连接，还取决于微管阵列的组织。

关键词

高尔基堆叠、再循环内体、高尔基带、微管、纤毛、海胆、海鞘。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/75c14746deb0/csf_49_24055-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/e1a813442601/csf_49_24055-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/e7477a5cec08/csf_49_24055-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/0e3dd6df1473/csf_49_24055-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/63be55b79cc5/csf_49_24055-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/75c14746deb0/csf_49_24055-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/e1a813442601/csf_49_24055-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/e7477a5cec08/csf_49_24055-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/0e3dd6df1473/csf_49_24055-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/63be55b79cc5/csf_49_24055-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcad/11930777/75c14746deb0/csf_49_24055-f005.jpg

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Cell Rep. 2024 Mar 26;43(3):113791. doi: 10.1016/j.celrep.2024.113791. Epub 2024 Feb 29.
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The Golgi Apparatus and its Next-Door Neighbors.高尔基体及其近邻
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Ciliogenesis membrane dynamics and organization.纤毛发生膜动力学和组织。
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Function of Centriolar Satellites and Regulation by Post-Translational Modifications.中心粒卫星的功能及翻译后修饰的调控
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Xenacoelomorph-Specific Hox Peptides: Insights into the Phylogeny of Acoels, Nemertodermatids, and Xenoturbellids.扁形动物门特有的 Hox 肽：环节动物、纽形动物和栉水母动物系统发育的见解。
Zoolog Sci. 2019 Oct;36(5):395-401. doi: 10.2108/zs190045.
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Sec71 separates Golgi stacks in S2 cells.Sec71在S2细胞中分离高尔基体堆叠。
J Cell Sci. 2020 Dec 29;133(24):jcs245571. doi: 10.1242/jcs.245571.
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Geographical Distribution and Genetic Diversity of (Acoelomorpha) in the Seto Inland Sea, Japan.日本濑户内海无肠目动物的地理分布与遗传多样性
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Recycling endosomes associate with Golgi stacks in sea urchin embryos.回收型内体在海胆胚胎中与高尔基体堆叠相关联。
Commun Integr Biol. 2020 Apr 30;13(1):59-62. doi: 10.1080/19420889.2020.1761069. eCollection 2020.
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Recycling endosomes attach to the trans-side of Golgi stacks in and mammalian cells.循环内体在酵母和哺乳动物细胞中与高尔基体堆栈的反面相连。
J Cell Sci. 2020 Feb 26;133(4):jcs236935. doi: 10.1242/jcs.236935.
10
A New Look at the Functional Organization of the Golgi Ribbon.高尔基体带状结构功能组织的新视角。
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