Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
J Clin Pathol. 2013 Aug;66(8):676-80. doi: 10.1136/jclinpath-2013-201454. Epub 2013 Apr 27.
To investigate the pathological and clinical meaning of p63 in extranodal nasal type NK/T cell lymphoma (NKTCL).
We detected p63 and p53 expression using immunohistochemistry staining in 84 cases of NKTCL from Southern of China, an area with a well known high incidence of nasopharyngeal carcinoma, which is closely associated with Epstein-Barr virus infection. Moreover, we analysed the relationship between p63 and p53 expression and the clinicopathological features of NKTCL.
Our results first showed that p63 expression was found in 14.3% (12/84) of NKTCL compared with 6.6% (2/30) in reactive lymphoid hyperplasia of nasopharynx. p63 Expression rate in NKTCL was significantly higher than that in reactive lymphoid hyperplasia of nasopharynx (p=0.016). NKTCL patients with p63 positivity had poorer 5-year overall survival rate (29.2%) than that (49.9%) of p63 negativity. p53 expression was found in 33.3% (28/84) of NKTCL. Our data showed that p53 expression was significantly associated with tumour stage (p=0.016) and international prognostic index (p=0.026) in patients with NKTCL. Cox regression test showed that p53 expression rate and international prognostic index score were statistically independent prognostic factors for NKTCL patients (p=0.002 and p=0.016, respectively). Our results suggest that p63 and p53 might play a role in pathogenesis of NKTCL.
研究 p63 在结外鼻型 NK/T 细胞淋巴瘤（NKTCL）中的病理和临床意义。
我们使用免疫组织化学染色法检测了来自中国南方 84 例 NKTCL 病例中 p63 和 p53 的表达，该地区鼻咽癌发病率很高，与 Epstein-Barr 病毒感染密切相关。此外，我们分析了 p63 和 p53 表达与 NKTCL 临床病理特征之间的关系。
我们的结果首次表明，与鼻咽反应性淋巴组织增生中的 6.6%（2/30）相比，p63 在 14.3%（12/84）的 NKTCL 中表达。NKTCL 中 p63 的表达率明显高于鼻咽反应性淋巴组织增生（p=0.016）。p63 阳性的 NKTCL 患者的 5 年总生存率（29.2%）低于 p63 阴性患者（49.9%）。在 33.3%（28/84）的 NKTCL 中发现了 p53 表达。我们的数据表明，p53 表达与 NKTCL 患者的肿瘤分期（p=0.016）和国际预后指数（p=0.026）显著相关。Cox 回归检验显示，p53 表达率和国际预后指数评分是 NKTCL 患者的统计学上独立的预后因素（p=0.002 和 p=0.016）。我们的结果表明，p63 和 p53 可能在 NKTCL 的发病机制中发挥作用。
