Redfors Björn, Shao Yangzhen, Omerovic Elmir
Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Vasc Health Risk Manag. 2013;9:149-54. doi: 10.2147/VHRM.S40163. Epub 2013 Apr 17.
Stress-induced cardiomyopathy (SIC), also known as Takotsubo cardiomyopathy, is characterized by severe but potentially reversible regional left ventricular wall motion abnormalities, ie, akinesia, in the absence of explanatory angiographic evidence of a coronary occlusion. The typical pattern is that of an akinetic apex with preserved contractions in the base, but other variants are also common, including basal or midmyocardial akinesia with preserved apical function. The pathophysiology of SIC remains largely unknown but catecholamines are believed to play a pivotal role. The diverse array of triggering events that have been linked to SIC are arbitrarily categorized as either emotional or somatic stressors. These categories can be considered as different elements of a continuous spectrum, linked through the interface of neurology and psychiatry. This paper reviews our current knowledge of SIC, with focus on the intimate relationship between the brain and the heart.
应激性心肌病（SIC），也称为Takotsubo心肌病，其特征是左心室壁出现严重但可能可逆的局部运动异常，即运动不能，且冠状动脉造影无冠状动脉闭塞的解释性证据。典型表现为心尖运动不能而心底收缩功能保留，但其他变异型也很常见，包括基底段或心肌中层运动不能而心尖功能保留。SIC的病理生理学在很大程度上仍不清楚，但儿茶酚胺被认为起关键作用。与SIC相关的一系列触发事件被任意分类为情感性或躯体性应激源。这些类别可被视为连续谱的不同元素，通过神经学和精神病学的界面联系在一起。本文综述了我们目前对SIC的认识，重点关注大脑与心脏之间的密切关系。
