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青少年晚期肝细胞癌合并先天性胆汁淤积症:病例报告

Advanced hepatocellular carcinoma in adolescence associated with congenital cholestasis: a case description.

作者信息

Ladekarl Morten, Villadsen Gerda Elisabeth, Rudbeck Anne Roed, Aagenæs Oystein, Nielsen Jens Erik, Hamilton-Dutoit Stephen, Nordsmark Marianne

机构信息

Department of Oncology, Aarhus University Hospital, Aarhus, Denmark, Norway.

出版信息

Case Rep Oncol. 2013 Feb 19;6(1):98-103. doi: 10.1159/000348715. Print 2013 Jan.

DOI:10.1159/000348715
PMID:23626552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3617980/
Abstract

This case describes the clinical course and treatment of a 17-year-old male patient with advanced hepatocellular carcinoma (HCC) arising in a non-cirrhotic liver. The disease was thought to be caused by a congenital cholestatic syndrome associated with intermittent oedema in childhood, resembling the rare Aagenaes syndrome. Treatment choices in advanced HCC arising in adolescence are discussed.

摘要

本病例描述了一名17岁男性患者的临床病程及治疗情况,该患者患有非肝硬化肝脏中发生的晚期肝细胞癌(HCC)。该疾病被认为是由一种先天性胆汁淤积综合征引起的,该综合征在儿童期伴有间歇性水肿,类似于罕见的阿格内斯综合征。文中讨论了青少年晚期肝细胞癌的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db38/3617980/16b1f1c36271/cro-0006-0098-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db38/3617980/5f92e1f7adce/cro-0006-0098-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db38/3617980/f30793c3fee4/cro-0006-0098-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db38/3617980/16b1f1c36271/cro-0006-0098-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db38/3617980/5f92e1f7adce/cro-0006-0098-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db38/3617980/f30793c3fee4/cro-0006-0098-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db38/3617980/16b1f1c36271/cro-0006-0098-g03.jpg

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本文引用的文献

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A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report.索拉非尼治疗耐药性实体瘤或白血病儿童的 I 期临床试验和药代动力学研究:儿童肿瘤学组 I 期联盟报告。
Clin Cancer Res. 2012 Nov 1;18(21):6011-22. doi: 10.1158/1078-0432.CCR-11-3284. Epub 2012 Sep 7.
2
Complete response of advanced hepatocellular carcinoma with multiple lung metastases treated with sorafenib: a case report.索拉非尼治疗伴多发肺转移的晚期肝细胞癌完全缓解 1 例报告
Oncology. 2011;81 Suppl 1:152-7. doi: 10.1159/000333279. Epub 2011 Dec 22.
3
Critical review of controversial issues in the management of advanced pediatric liver tumors.
儿童肝肿瘤治疗中争议问题的批判性回顾
Pediatr Blood Cancer. 2011 Jul 1;56(7):1013-8. doi: 10.1002/pbc.22893. Epub 2010 Dec 1.
4
Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial.多柔比星联合索拉非尼对比多柔比星单药治疗晚期肝细胞癌的随机试验。
JAMA. 2010 Nov 17;304(19):2154-60. doi: 10.1001/jama.2010.1672.
5
Complete response of hepatocellular carcinoma with systemic combination chemotherapy: not to get out the chemotherapy?肝癌的系统联合化疗完全缓解:是否要停止化疗?
Eur J Gastroenterol Hepatol. 2010 Aug;22(8):1015-8. doi: 10.1097/MEG.0b013e328336565a.
6
Fibrolamellar hepatocellular carcinoma in an infant and literature review.婴儿纤维板层型肝细胞癌及文献综述
J Pediatr Hematol Oncol. 2008 Dec;30(12):968-71. doi: 10.1097/MPH.0b013e31818b0f82.
7
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8
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