先前感染的流感病毒可保护小鼠免受致死性流感病毒的攻击。
[Prior infected influenza virus could protect mice from challenge of lethal influenza virus].
作者信息
Liu Li-Qi, Li Zi, Zhu Yun, Shu Yue-Long
机构信息
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, WHO Collaborating Center for Reference and Research on Influenza, 155 Changbai Road, Bejing 102206, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):405-8.
OBJECTIVE
To determine whether it could protect mice from challenge of lethal influenza virus which group prior infected A(H1N1) pdm09 and H9N2 virus respectively.
METHODS
150 BALB/c mice are divided into three groups. Mice are infected A(H1N1) pdm09 virus (pCA07) and poultry H9N2 virus (GZ333) respectively. Infected mice are challenged with 10 times of lethal dose virus (PR8) then compare the viral load, antibody and survival of the two group mice before and after challenged.
RESULTS
Both experimental group mice survived after challenge of lethal influenza virus and lung viral load are lower than that of the first infection. Antibodies derived from the infective virus and challenge virus.
CONCLUSION
Prior infected A(H1N1) pdm09 and H9N2 virus could protect mice from challenge of lethal influenza virus.
目的
确定先前分别感染甲型（H1N1）pdm09和H9N2病毒的小鼠组是否能保护其免受致死性流感病毒的攻击。
方法
将150只BALB/c小鼠分为三组。小鼠分别感染甲型（H1N1）pdm09病毒（pCA07）和禽H9N2病毒（GZ333）。对感染后的小鼠用10倍致死剂量的病毒（PR8）进行攻击，然后比较两组小鼠攻击前后的病毒载量、抗体水平和存活率。
结果
两个实验组的小鼠在受到致死性流感病毒攻击后均存活，且肺部病毒载量低于初次感染时。抗体来源于感染病毒和攻击病毒。
结论
先前感染甲型（H1N1）pdm09和H9N2病毒可保护小鼠免受致死性流感病毒的攻击。
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