Wung Deanna
University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Int J Pharm Compd. 2013 Jan-Feb;17(1):24-7.
The drugs tadalafil and sildenafil share the same mechanism. Although more research is necessary to solidify the recommendation of the routine use of tadalafil, human and dog data combined with pharmacokinetic data suggest that dogs may be safely treated for canine pulmonary arterial hypertension with tadalafil for the convenience of less frequent dosing, with effects similar to sildenafil. While more costly, the use of tadalafil has positive implications in improving compliance and, therefore, therapeutic outcomes in canine pulmonary arterial hypertension. This article explores the data for the use of tadalafil in canine pulmonary arterial hypertension and provides example compounded preparations.
他达拉非和西地那非具有相同的作用机制。虽然需要更多研究来确定常规使用他达拉非的建议，但结合人体和犬类数据以及药代动力学数据表明，他达拉非可安全用于治疗犬类肺动脉高压，因其给药频率较低，且效果与西地那非相似。虽然他达拉非成本更高，但在改善犬类肺动脉高压的依从性以及治疗效果方面具有积极意义。本文探讨了他达拉非用于犬类肺动脉高压的数据，并提供了复方制剂示例。
