Department of Neurology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
J Neurol Sci. 2013 Jul 15;330(1-2):52-5. doi: 10.1016/j.jns.2013.04.003. Epub 2013 Apr 26.
Cigarette smoking seems to contribute to susceptibility and progression of multiple sclerosis (MS).Although the incidence of MS in Iranian population has increased during recent years, the effects of smoking on progression of MS have not been studied. The aim of this study was to investigate the association between cigarette smoking and development of secondary progressive MS (SPMS) in Iranian patients with MS.
This study was carried out on patients registered in the MS Society (Guilan, Iran) database. Using a structured questionnaire, information on smoking status of 400 of patients could be obtained. The association between cigarettes smoking and SPMS was analyzed by Cox regression model.
The relationship between smoking and development of SPMS was still evident after adjusting for age at disease onset, gender and number of relapses per year (P =0.004). Smoking more than 10 cigarettes per day increased risk of development of SPMS (HR: 2.43; 95% CI: 1.28 to 4.6; P =0.007).
Our results indicated that smokers have an increased risk for progression of relapsing-remitting MS (RRMS) to SPMS compared with non-smokers. We also showed that the disease progression may be influenced by increase of cigarette smoking.
吸烟似乎会增加多发性硬化症（MS）的易感性和进展。尽管近年来伊朗人口中 MS 的发病率有所增加，但吸烟对 MS 进展的影响尚未得到研究。本研究旨在调查伊朗 MS 患者吸烟与继发进展性 MS（SPMS）发展之间的关联。
本研究在 MS 协会（伊朗吉兰）数据库中登记的患者中进行。使用结构化问卷，可以获得 400 名患者的吸烟状况信息。通过 Cox 回归模型分析吸烟与 SPMS 之间的关联。
在调整发病年龄、性别和每年复发次数后，吸烟与 SPMS 发展之间仍存在明显关系（P =0.004）。每天吸烟超过 10 支会增加发展为 SPMS 的风险（HR：2.43；95% CI：1.28 至 4.6；P =0.007）。
我们的结果表明，与不吸烟者相比，吸烟者进展为复发缓解型 MS（RRMS）为 SPMS 的风险增加。我们还表明，吸烟量的增加可能会影响疾病的进展。
