基于发夹探针辅助级联信号放大的多重 DNA 检测通用生物传感器。
A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification.
机构信息
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
出版信息
Chem Commun (Camb). 2013 Jun 7;49(45):5165-7. doi: 10.1039/c3cc41941j.
PMID:23628952
Abstract
A hairpin DNA probe mediated cascade signal amplification method was developed for visual and rapid DNA analysis with a detection limit of 100 aM. The implementation of tag/anti-tag DNA and gold nanoparticle reporters permits a universal platform for multiplex genotyping without instrumentation.
摘要
发夹 DNA 探针介导的级联信号放大方法，用于可视化和快速 DNA 分析，检测限为 100 aM。标签/反标签 DNA 和金纳米粒子报告分子的实现允许在没有仪器的情况下通用的多重基因分型平台。
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