• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

转化医学:降低研究者风险。

Translational medicine: mitigating risks for investigators.

机构信息

Center for Cardiovascular Research, Division of Cardiology and at the Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8086, St Louis, Missouri 63110, USA.

出版信息

Nat Rev Drug Discov. 2013 May;12(5):327-8. doi: 10.1038/nrd4005.

DOI:10.1038/nrd4005
PMID:23629490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4283600/
Abstract

Although investigators are encouraged to translate their laboratory research to impact the care of patients, there is an unappreciated downside to participating in “T1 translation” from the standpoint of the investigator if their translational efforts do not yield positive results in pivotal clinical trials.

摘要

尽管鼓励研究人员将实验室研究转化为对患者护理的影响,但如果他们的转化努力在关键临床试验中没有产生积极结果,从研究人员的角度来看,参与“T1 转化”存在未被认识到的缺点。

相似文献

1
Translational medicine: mitigating risks for investigators.转化医学:降低研究者风险。
Nat Rev Drug Discov. 2013 May;12(5):327-8. doi: 10.1038/nrd4005.
2
Clinician scientists and PhDs: the need to connect basic research to translational medicine-a personal experience.临床医生科学家与博士:将基础研究与转化医学相联系的必要性——个人经历
J Invest Dermatol. 2014 Feb;134(2):295-298. doi: 10.1038/jid.2013.466.
3
Changes in NIH criteria for tenure to reward clinical/translational teams.美国国立卫生研究院(NIH)终身教职评定标准的变化,以奖励临床/转化研究团队。
Clin Transl Sci. 2010 Feb;3(1):4-5. doi: 10.1111/j.1752-8062.2009.00164.x.
4
Bridging the translation gap and building the translation platform: translational medicine at Peking Union Medical College Hospital.
Sci China Life Sci. 2016 Oct;59(10):1048-1050. doi: 10.1007/s11427-012-4363-2.
5
John Canty Jr: A Full Life, Both at Home and in the Lab.
Circ Res. 2017 Jun 9;120(12):1862-1864. doi: 10.1161/CIRCRESAHA.117.311329.
6
National Research Center for Translational Medicine · Shanghai-National Key Scientific Infrastructure for Translational Medicine.国家转化医学研究中心·上海-国家转化医学重大科技基础设施
Sci China Life Sci. 2016 Oct;59(10):1051-1054. doi: 10.1007/s11427-016-5099-1.
7
A Matrix Mentoring Model That Effectively Supports Clinical and Translational Scientists and Increases Inclusion in Biomedical Research: Lessons From the University of Utah.一种有效支持临床和转化科学家并增加生物医学研究包容性的矩阵指导模式:来自犹他大学的经验教训。
Acad Med. 2016 Apr;91(4):497-502. doi: 10.1097/ACM.0000000000001021.
8
Mentoring translational science investigators.指导转化科学研究人员。
JAMA. 2012 Nov 21;308(19):1981-2. doi: 10.1001/jama.2012.14367.
9
President's address. Allergy: at the academic/clinical interface.
J Allergy Clin Immunol. 1989 Jan;83(1):1-4. doi: 10.1016/0091-6749(89)90470-3.
10
The path from bench to bedside: considerations before starting the journey.从实验室到病床:启程前的思考。
J Investig Med. 2011 Jun;59(5):746-51. doi: 10.2310/JIM.0b013e3182160d70.

引用本文的文献

1
Translational research in biomedical sciences in India: Challenges, observations & national perspectives.印度生物医学科学领域的转化研究:挑战、观察与国家视角。
Indian J Med Res. 2020 Oct;152(4):335-341. doi: 10.4103/ijmr.IJMR_1296_19.
2
Awareness of and attitudes toward translational medicine among health personnel in hospitals in Shanghai, China.中国上海医院卫生人员对转化医学的认知与态度
J Int Med Res. 2019 Jan;47(1):438-452. doi: 10.1177/0300060518809242. Epub 2018 Nov 29.
3
The oxidative stress theory of disease: levels of evidence and epistemological aspects.疾病的氧化应激理论:证据水平与认识论方面
Br J Pharmacol. 2017 Jun;174(12):1784-1796. doi: 10.1111/bph.13544. Epub 2016 Aug 4.
4
A new cell-penetrating peptide that blocks the autoinhibitory XIP domain of NCX1 and enhances antiporter activity.一种新的细胞穿透肽,可阻断NCX1的自抑制XIP结构域并增强反向转运体活性。
Mol Ther. 2015 Mar;23(3):465-76. doi: 10.1038/mt.2014.231. Epub 2014 Dec 11.

本文引用的文献

1
Myocardial salvage in acute myocardial infarction--challenges in clinical translation.急性心肌梗死中的心肌挽救——临床转化面临的挑战
J Mol Cell Cardiol. 2011 Oct;51(4):451-3. doi: 10.1016/j.yjmcc.2011.08.002. Epub 2011 Aug 12.
2
Trends in risks associated with new drug development: success rates for investigational drugs.新药研发相关风险趋势:研究药物的成功率。
Clin Pharmacol Ther. 2010 Mar;87(3):272-7. doi: 10.1038/clpt.2009.295. Epub 2010 Feb 3.
3
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.西地那非:从心绞痛到勃起功能障碍,再到肺动脉高压及其他领域。
Nat Rev Drug Discov. 2006 Aug;5(8):689-702. doi: 10.1038/nrd2030.
4
Hemodynamic predictors of early intolerance and long-term effects of propranolol in dilated cardiomyopathy.普萘洛尔对扩张型心肌病早期耐受性及长期影响的血流动力学预测因素
J Card Fail. 1996 Dec;2(4):273-7. doi: 10.1016/s1071-9164(96)80013-3.