Pepin J L, Levy P, Lepaulle B, Bonnet C, Romand P, Pison C, Wuyam B, Colonna M, Paramelle B, Brambilla C
Service de Pneumologie, C.H.R.U. de Grenoble.
Rev Mal Respir. 1990;7(3):239-48.
The aim of this study was to test the efficacy of nocturnal oximetry as a means of continuous recording of SaO2 in the identification of apnoeic events in the recognition of non-apnoeic desaturation. The oscillations of SaO2 in relation to successive periods of apnoea during the course of the sleep apnoea syndrome (SAS) or with apnoeic episodes in patients with chronic airflow obstruction (BPCO) or restricted disease, were identified using a new delta index quantifying the variations of SaO2 during the night. 26 successive patients in whom there was an indication for nocturnal oximetry were included in a prospective study comparing nocturnal oximetry and polysomnography during 34 nights. In the apnoeic patients we found a strong correlation (r = .85. p. less than .01) between the apnoeic period and the delta index. In BPCO the number of apnoea was correlated with the delta index (r = .96. p. less than .01). A minimal threshold of the delta index fixed at 1.5 was satisfactory for detecting apnoea if the initial SaO2 was less than 93%. The value of the adequate for affected detection ought to be fixed at .8 (95% sensitivity) when the initial SaO2 was greater than 93%. A detection of apnoeic events thus seems possible by this method.
本研究的目的是测试夜间血氧饱和度测定作为一种连续记录动脉血氧饱和度(SaO2)的方法,在识别呼吸暂停事件以及非呼吸暂停性血氧饱和度降低方面的有效性。使用一种新的δ指数来量化夜间SaO2的变化,从而确定睡眠呼吸暂停综合征(SAS)过程中与连续呼吸暂停期相关的SaO2振荡,以及慢性气流阻塞(BPCO)或限制性疾病患者的呼吸暂停发作情况。26例有夜间血氧饱和度测定指征的连续患者被纳入一项前瞻性研究,在34个夜晚比较夜间血氧饱和度测定和多导睡眠图。在呼吸暂停患者中,我们发现呼吸暂停期与δ指数之间存在强相关性(r = 0.85,p < 0.01)。在BPCO患者中,呼吸暂停次数与δ指数相关(r = 0.96,p < 0.01)。如果初始SaO2小于93%,将δ指数的最小阈值设定为1.5对于检测呼吸暂停是令人满意的。当初始SaO2大于93%时,用于有效检测的δ指数值应设定为0.8(敏感性为95%)。因此,通过这种方法似乎有可能检测到呼吸暂停事件。