多发性皮肤和子宫平滑肌瘤综合征：综述
Multiple cutaneous and uterine leiomyomatosis syndrome: a review.
作者信息
Choudhary Sonal, McLeod Michael, Torchia Daniele, Romanelli Paolo
机构信息
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
出版信息
J Clin Aesthet Dermatol. 2013 Apr;6(4):16-21.
Abstract
Multiple cutaneous and uterine leiomyomatosis is an autosomal dominant disease characterized by leiomyomas of the skin and uterus. A small proportion of patients affected by multiple cutaneous and uterine leiomyomatosis will develop renal cell carcinoma and this condition is known as hereditary leiomyomatosis and renal cell carcinoma. Diagnosis usually occurs during histological analysis of a cutaneous biopsy. Management should involve a multidisciplinary team along with periodical radiological studies to closely monitor tumor size in the uterus and kidneys. Gonadotropin-releasing hormone analogues are helpful in reducing the size of uterine fibroids.
摘要
多发性皮肤和子宫平滑肌瘤病是一种常染色体显性疾病，其特征为皮肤和子宫的平滑肌瘤。一小部分患有多发性皮肤和子宫平滑肌瘤病的患者会发展为肾细胞癌，这种情况被称为遗传性平滑肌瘤病和肾细胞癌。诊断通常在皮肤活检的组织学分析过程中进行。治疗应包括多学科团队以及定期的放射学检查，以密切监测子宫和肾脏肿瘤的大小。促性腺激素释放激素类似物有助于缩小子宫肌瘤的大小。
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