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[功能量子点在癌症诊断与治疗中的应用:综述]

[Application of functional quantum dots in cancer diagnosis and therapy: a review].

作者信息

Han Shuang, Xia Tian, Li Qingning, Guo Junming, Lu Peibei

机构信息

Medical School, Ningbo University, Ningbo 315211, Zhejiang, China.

出版信息

Sheng Wu Gong Cheng Xue Bao. 2013 Jan;29(1):10-20.

Abstract

Quantum dots (QDs) are nanometer-sized luminescent semiconductor nanocrystals. Their unique optical properties, such as high brightness, long-term stability, simultaneous detection of multiple signals and tunable emission spectra, make them appealing as potential diagnostic and therapeutic systems in oncology. Preparing the functional QDs by modifying bio-molecules such as antibody will have potential value for cancer diagnosis and treatment. This paper summarized the recent progress of promising application of QDs in cancer diagnosis and therapy, from identifying molecular targets, to drug delivery and therapy; from limitations of toxicity issues related to QDs in living organisms to multifunctional design and development. Finally, the promising applications of QDs are also discussed.

摘要

量子点(QDs)是纳米尺寸的发光半导体纳米晶体。它们独特的光学特性,如高亮度、长期稳定性、多信号同时检测以及可调发射光谱,使其作为肿瘤学中潜在的诊断和治疗系统具有吸引力。通过修饰生物分子(如抗体)来制备功能性量子点对于癌症诊断和治疗具有潜在价值。本文综述了量子点在癌症诊断和治疗中有望应用的最新进展,从识别分子靶点到药物递送和治疗;从量子点在生物体中相关毒性问题的局限性到多功能设计与开发。最后,还讨论了量子点的应用前景。

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