Kukes V G, Zhernakova N I, Gorbach T V, Romashchenko O V, Rumbesht V V
Eksp Klin Farmakol. 2013;76(2):9-12.
Introduction of trimetazidine to 10-month-aged rats with experimental ischemic heart disease leads to an increase in carbohydrate utilization with energy purposes in myocardium, which is manifested by increasing activity of glycolysis enzymes with decreasing lactate level in myocardium, increasing activity of pyruvate dehydrogenase and citrate synthase in mitochondrial cardiomyocytes, and increasing ATP content in myocardium. This is accompanied by signs of stabilization of cardiomyocyte membranes and reduction in the degree of tissue hypoxia. The efficiency of trimetazidine decreases with increasing age: in 24-month-aged rats, the direction of changes is retained, but they are less pronounced.
将曲美他嗪应用于10月龄实验性缺血性心脏病大鼠，可导致心肌中用于能量目的的碳水化合物利用率增加，表现为糖酵解酶活性增加，心肌中乳酸水平降低，线粒体心肌细胞中丙酮酸脱氢酶和柠檬酸合酶活性增加，以及心肌中ATP含量增加。这伴随着心肌细胞膜稳定的迹象以及组织缺氧程度的降低。曲美他嗪的疗效随年龄增长而降低：在24月龄大鼠中，变化方向保持不变，但不那么明显。
