Eide P K
Fysiologisk institutt, Universitetet i Bergen.
Tidsskr Nor Laegeforen. 1990 May 30;110(14):1812-4.
The rationale for neurosurgical treatment of chronic pain is based on the knowledge of the processing of pain in the nervous system. Pain research during the last twenty years has clearly affected the attitude towards neurosurgical management of pain. Destructive neurosurgical procedures which attempt to block the transmission of pain. possess several drawbacks from a physiological point of view. Electrical stimulation of the nervous system activating endogenous pain controlling mechanisms does not require destruction of nervous tissue, and takes into account the dynamic aspects of pain regulation. Other neurosurgical operations have also been shown to relieve pain, although the physiological mechanisms involved are still unknown.
慢性疼痛神经外科治疗的理论依据基于对神经系统疼痛处理过程的认识。过去二十年的疼痛研究明显影响了对疼痛神经外科治疗的态度。试图阻断疼痛传导的破坏性神经外科手术，从生理学角度来看有几个缺点。激活内源性疼痛控制机制的神经系统电刺激不需要破坏神经组织，并且考虑到了疼痛调节的动态方面。其他神经外科手术也已被证明可缓解疼痛，尽管其中涉及的生理机制仍不清楚。
