Michigan Nanotechnology Institute, University of Michigan, Ann Arbor, MI, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Sep-Oct;5(5):423-9. doi: 10.1002/wnan.1226. Epub 2013 Apr 30.
Nanoparticles are the only materials small enough to target cells in the body, and therefore are crucial to targeted drug delivery. Issues with the synthesis, consistency, and bioactivity of these molecules are still being addressed, but base on current proof of concept studies there is a reason to believe that the 'holy grail' of targeted drug delivery might someday be achieved using nanoparticle-based systems.
纳米颗粒是唯一小到足以靶向体内细胞的材料,因此对靶向药物输送至关重要。这些分子的合成、一致性和生物活性方面仍存在问题,但基于当前的概念验证研究,有理由相信,有朝一日,使用基于纳米颗粒的系统可能实现靶向药物输送的“圣杯”。