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1,4-双(3-氯-吡嗪-2-基-氧基)苯

1,4-Bis(3-chloro-pyrazin-2-yl-oxy)benzene.

作者信息

Srinivasan Thothadri, Kalpana Venkatesan, Rajakumar Perumal, Velmurugan Devadasan

机构信息

Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 28;69(Pt 4):o611. doi: 10.1107/S1600536813007824. Print 2013 Apr 1.

DOI:10.1107/S1600536813007824
PMID:23634136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3629649/
Abstract

In the title compound, C14H8Cl2N4O2, the pyrazine rings are orthogonal to the benzene ring, making dihedral angles of 88.42 (8) and 89.22 (8)°. The Cl atoms attached to the pyrazine rings deviate by -0.0597 (5) and 0.0009 (5) Å from the ring plane. The crystal structure features C-H⋯N hydrogen bonds.

摘要

在标题化合物C₁₄H₈Cl₂N₄O₂中，吡嗪环与苯环正交，二面角为88.42 (8)°和89.22 (8)°。连接在吡嗪环上的氯原子偏离环平面的距离分别为-0.0597 (5) Å和0.0009 (5) Å。晶体结构具有C-H⋯N氢键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b04/3629649/6e1d668647e9/e-69-0o611-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b04/3629649/1d388187bd87/e-69-0o611-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b04/3629649/6e1d668647e9/e-69-0o611-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b04/3629649/1d388187bd87/e-69-0o611-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b04/3629649/6e1d668647e9/e-69-0o611-fig2.jpg

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本文引用的文献

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Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 31;66(Pt 8):o2187. doi: 10.1107/S160053681003014X.
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Imidazo-pyrazine derivatives as potent CXCR3 antagonists.作为强效CXCR3拮抗剂的咪唑并吡嗪衍生物
Bioorg Med Chem Lett. 2009 Sep 1;19(17):5200-4. doi: 10.1016/j.bmcl.2009.07.021. Epub 2009 Jul 9.
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Structure validation in chemical crystallography.化学晶体学中的结构验证
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Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.
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Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke.咪唑并[1,5-a]吡嗪衍生物作为急性缺血性中风治疗药物的合成及其对c-Src的抑制活性
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