靶向治疗大颗粒淋巴细胞白血病中的白介素 15。
Targeting IL-15 in large granular lymphocyte leukemia.
机构信息
Penn State Hershey Cancer Institute, 500 University Drive, Hershey, PA 17033, USA.
出版信息
Expert Rev Clin Immunol. 2013 May;9(5):405-8. doi: 10.1586/eci.13.28.
Abstract
IL-15 is a cytokine that stimulates the proliferation of NK and T cells. Previous studies have shown that IL-15 is critical to the induction of T-cell large granular lymphocyte (T-LGL) leukemia. A Phase I trial of a humanized antibody (Hu-Mikβ1) to the IL2/IL15Rβ receptor, expressed on T-LGL, is explored in this trial to evaluate the safety, pharmacokinetics, specificity and clinical efficacy of Hu-Mikβ1. The study demonstrated no toxicity and favorable saturation of IL2/IL15Rβ receptor, but no clinical efficacy in this Phase I study.
摘要
IL-15 是一种细胞因子，可刺激 NK 和 T 细胞的增殖。先前的研究表明，IL-15 对诱导 T 细胞大颗粒淋巴细胞（T-LGL）白血病至关重要。本试验研究了一种针对 T-LGL 上表达的 IL2/IL15Rβ 受体的人源化抗体（Hu-Mikβ1）的 I 期临床试验，以评估 Hu-Mikβ1 的安全性、药代动力学、特异性和临床疗效。该研究表明，该试验中无毒性和 IL2/IL15Rβ 受体的良好饱和，但无临床疗效。
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