Loh Beng-In, Sathyasuryan Daniel Robert, Mohamed Hamid Jan Jan
Universiti Sains Malaysia, Kelantan, Malaysia.
Asia Pac J Clin Nutr. 2013;22(2):241-8. doi: 10.6133/apjcn.2013.22.2.04.
Adiponectin, an adipocyte-derived hormone has been implicated in the control of blood glucose and chronic inflammation in type 2 diabetes. However, limited studies have evaluated dietary factors on plasma adiponectin levels, especially among type 2 diabetic patients in Malaysia. The aim of this study was to investigate the influence of dietary glycemic index on plasma adiponectin concentrations in patients with type 2 diabetes. A cross-sectional study was conducted in 305 type 2 diabetic patients aged 19-75 years from the Penang General Hospital, Malaysia. Socio-demographic information was collected using a standard questionnaire while dietary details were determined by using a pre-validated semi-quantitative food frequency questionnaire. Anthropometry measurement included weight, height, BMI and waist circumference. Plasma adiponectin concentrations were measured using a commercial ELISA kit. Data were analyzed using multiple linear regression. After multivariate adjustment, dietary glycemic index was inversely associated with plasma adiponectin concentrations (β =-0.272, 95% CI -0.262, - 0.094; p<0.001). It was found that in individuals who consumed 1 unit of foods containing high dietary glycemic index that plasma adiponectin level reduced by 0.3 μg/mL. Thirty two percent (31.9%) of the variation in adiponectin concentrations was explained by age, sex, race, smoking status, BMI, waist circumference, HDL-C, triglycerides, magnesium, fiber and dietary glycemic index according to the multiple linear regression model (R2=0.319). These results support the hypothesis that dietary glycemic index influences plasma adiponectin concentrations in patients with type 2 diabetes. Controlled clinical trials are required to confirm our findings and to elucidate the underlying mechanism.
脂联素是一种由脂肪细胞分泌的激素，与2型糖尿病患者的血糖控制和慢性炎症有关。然而，评估饮食因素对血浆脂联素水平影响的研究有限，尤其是在马来西亚的2型糖尿病患者中。本研究旨在探讨饮食血糖指数对2型糖尿病患者血浆脂联素浓度的影响。对马来西亚槟城总医院305名年龄在19至75岁之间的2型糖尿病患者进行了一项横断面研究。使用标准问卷收集社会人口学信息，同时使用经过预验证的半定量食物频率问卷确定饮食细节。人体测量包括体重、身高、体重指数和腰围。使用商业酶联免疫吸附测定试剂盒测量血浆脂联素浓度。采用多元线性回归分析数据。经过多变量调整后，饮食血糖指数与血浆脂联素浓度呈负相关（β=-0.272，95%可信区间-0.262，-0.094；p<0.001）。研究发现，在摄入1单位高饮食血糖指数食物的个体中，血浆脂联素水平降低了0.3μg/mL。根据多元线性回归模型（R2=0.319），年龄、性别、种族、吸烟状况、体重指数、腰围、高密度脂蛋白胆固醇、甘油三酯、镁、纤维和饮食血糖指数解释了脂联素浓度32%（31.9%）的变化。这些结果支持了饮食血糖指数影响2型糖尿病患者血浆脂联素浓度这一假设。需要进行对照临床试验来证实我们的发现并阐明潜在机制。
